The men’s draw also looks open after surprise defeats for 24-time Grand Slam winner Novak Djokovic and reigning French Open and Wimbledon champion Carlos Alcaraz.

Australia Open champion Jannik Sinner and Daniil Medvedev, who won the title in New York in 2021, are in the top half of the draw, leaving Fritz, Zverev, Tiafoe and Dimitrov in the bottom.

Tiafoe, seeded 20th this year, reached the semi-finals in 2022, where he lost in five sets to Alcaraz, while 12th seed Fritz has not progressed from any of his four Grand Slam quarter-finals to date.

There has not been an American winner of the US Open men’s singles since Andy Roddick in 2003.

“In the past, I’ve been very, very excited, to make quarter-finals at Slams,” Fritz said.

“I’m at the point now where I’m still happy to make them but I wouldn’t be happy with it ending here.

“I am at the point where I really want more than that.”

His opponent, Germany’s Zverev, reached the final of the French Open this year and at Flushing Meadows in 2020, but was beaten by Fritz at Wimbledon this year.

“[Taylor] played an amazing tournament at Wimbledon,” Zverev said.

“Every time I play Taylor, it’s a tough battle, so I’m expecting nothing less, and hopefully it will be entertaining.”