Flavio Cobolli will face the winner of the match between Pole Hubert Hurkacz, the No 5 seed, and Japanese qualifier Yoshihito Nishioka next.

Ahead of his victory, Cobolli edged out American Tommy Paul, the No 10 seed (6-2, 4-6, 7-5).

Luciano Darderi won against Chilean Alejandro Tabilo (6-3, 7-6 (5)) in the previous round of the Cincy Open.

Cincinnati Masters 1000, other second-round results (Lindner Family Tennis Center, hard, USD 6.795.555, most recent results first):

• Casper Ruud vs. Felix Auger-Aliassime
• Gael Monfils vs. Carlos Alcaraz
• Holger Rune vs. Nuno Borges
• Ben Shelton vs. Tomas Martin Etcheverry
• Jack Draper vs. Stefanos Tsitsipas
• Brandon Nakashima vs. Arthur Fils
• Fabian Marozsan vs. Grigor Dimitrov
• Max Purcell vs. Pablo Carreno Busta
• Zhizhen Zhang vs. Andrey Rublev
• Hubert Hurkacz vs. Yoshihito Nishioka: thursday
• Alexander Zverev vs. Karen Khachanov: thursday
• Jiri Lehecka beat Daniil Medvedev (4): 7-6 (2), 6-4
• Jordan Thompson beat Sebastian Baez: 6-2, 6-4
• Frances Tiafoe beat Lorenzo Musetti (14): 6-3, 6-2
• Jannik Sinner (1) beat Alex Michelsen (Q): 6-4, 7-5