The San Antonio Spurs (15-13) and the Philadelphia 76ers (9-17) square off in a cross-conference showdown on Monday evening. The Spurs enter this matchup on a two-game winning streak and having won four of their last five. San Antonio knocked off the Portland Trail Blazers 114-94 on Saturday. Meanwhile, the Philadelphia 76ers lost 136-99 to the Cleveland Cavaliers in their previous game. Joel Embiid (sinus fracture) is available and will play with a protective mask.

Tipoff from Wells Fargo Center in Philadelphia is 7 p.m. ET. Philadelphia is a 5.5-point favorite in the latest Spurs vs. 76ers odds via SportsLine consensus, while the over/under for total points scored is 217. Before locking in any 76ers vs. Spurs picks, make sure to check out the NBA predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters Week 9 of the 2024-25 NBA season on a sizzling 124-84 roll on all top-rated NBA picks dating back to last season, returning more than $3,000. Anyone following at sportsbooks and on betting apps has seen huge returns.

Now, the model has simulated Spurs vs. Sixers 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model’s picks. Here are several NBA odds and NBA betting lines for Sixers vs. Spurs:

• Spurs vs. 76ers spread: Philadelphia -5.5
• Spurs vs. 76ers over/under: 217 points
• Spurs vs. 76ers money line: Philadelphia -217, San Antonio +178
• SA: The Spurs are 13-15 against the spread this season 
• PHI: The 76ers are 10-16 against the spread this season 
• Spurs vs. 76ers picks: See picks at SportsLine
• Spurs vs. 76ers streaming: FuboTV (Try for free)

Why the Spurs can cover

Center Victor Wembanyama is a disruptive and all-around force for the Spurs. Wembanyama leads the team in both points (24.7) and rebounds (10) with 3.9 assists per game. He also leads the NBA in blocks (3.8). In his last outing, the 20-year-old had 30 points, seven rebounds and 10 assists. This was his 11th double-double of the season. 

Guard Devin Vassell is a smooth-shot creator with a reliable mid-range jumper. He averages 16.2 points, 2.4 rebounds and 2.5 assists per game. Vassell has scored at least 20 points in five of his 13 games this season. On Dec. 19 against the Hawks, he finished with 23 points, four rebounds and went 5-of-7 from beyond the arc. See which team to back at SportsLine.

Why the 76ers can cover

Guard Tyrese Maxey is a crafty ball handler and three-level scorer for the 76ers. Maxey owns the jumper to keep defenders on edge. The Kentucky product is 13th in the NBA in points (25.1) with 3.6 rebounds and five assists per game. He’s finished with 20-plus points in five straight games. In his last matchup, Maxey had 27 points, three dimes, and went 5-of-10 from downtown.

Forward Paul George provides the team with an athletic and lengthy presence in the frontcourt. George can knock down perimeter shots and plays solid defense as well. In 2024, he averages 16 points, 5.6 rebounds, and 5.1 assists per game. In the Dec. 16 win over the Charlotte Hornets, George had 33 points, five rebounds and eight assists. 

How to make Spurs vs. 76ers picks

SportsLine’s model is leaning Under the total, projecting 218 combined points. The model also says one side of the spread hits in well over 50% of simulations. You can head to SportsLine to see the model’s picks. 

So who wins Spurs vs. 76ers on Monday, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Spurs vs. 76ers spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.