No. 3 Penn State can essentially solidify a spot in the College Football Playoff when it hosts No. 4 Ohio State on Saturday in the most impactful game on the Week 10 college football schedule. The Nittany Lions are unbeaten heading into this contest, and their final four games are all against unranked opponents. However, they are 3.5-point home underdogs in the Week 10 college football odds, as head coach James Franklin is just 1-9 in his 10 meetings with the Buckeyes. Should you back Ohio State as a road favorite with your Week 10 college football bets?

Other important Week 10 college football spreads include No. 1 Oregon (-14.5) at Michigan (3:30 p.m. ET, CBS), No. 13 Indiana (-7.5) at Michigan State and No. 10 Texas A&M (-3) at South Carolina. Winning on the road in college football can be a difficult task, so it is important to read through quality Week 10 college football advice. Before you make any Week 10 college football picks and college football score predictions, you need to see the college football against the spread, over/under, and money line predictions powered by the self-learning SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine’s Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team’s historical data and then quantitatively evaluating the strength of the opponent’s defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine’s AI PickBot has hit a whopping 1,947 4.5- and 5-star NFL picks since the start of last season. Anyone who has followed it is way up at their best sports betting app and favorite betting sites. 

For Week 10 college football betting, the AI PickBot has evaluated the college football odds and provided college football betting picks for every game. You can only see the AI predictions for the Week 10 college football schedule here.

Top Week 10 college football AI picks

After analyzing every game in Week 10, the AI PickBot says the No. 18 Pittsburgh Panthers (+7.5, 57.5) easily cover on the road against the No. 20 SMU Mustangs in an 8 p.m. ET kickoff on Saturday. Pittsburgh has passed every test on its schedule so far this season, remaining unbeaten with a 41-13 win against Syracuse last Thursday. The Panthers were only 5-point favorites in that game, but they used three defensive touchdowns to take full control of the contest. 

Head coach Pat Narduzzi had said the Panthers were taking a “wait-and-see” approach regarding the status of starting quarterback Eli Holstein, but Narduzzi announced that Holstein got cleared to play on Wednesday. The redshirt freshman transfer from Alabama has 1,808 passing yards with 17 touchdowns in seven games this season. SMU quarterback Kevin Jennings is also banged up after taking a hit to his knee in a win over Duke last week. 

While Pittsburgh is entering this game with two extra days of rest, the Mustangs are coming off an overtime road win over the Blue Devils on standard rest. This advantage is one reason why the AI PickBot is predicting Pittsburgh to win this game outright to earn an A+ rating on the spread. See its other Week 10 college football predictions and football picks at SportsLine.

How to make Week 10 college football picks

In addition, the AI PickBot has generated a dozen other A-rated spread picks for Week 10. You need to see the AI PickBot’s college football picks before making any Week 10 college football bets of your own. You can only see them at SportsLine.

Who wins and covers each Week 10 college football game, and which A-rated picks should you target now? Visit SportsLine now to see the top college football picks against the spread, over/under, and on money line, all from the brand-new SportsLine AI PickBot that has nailed 1,947 top-rated NFL picks since the start of last season.