The No. 6 Oregon Ducks (4-0, 1-0) return to Autzen Stadium on Friday night to host the Michigan State Spartans (3-2, 1-1) in a Week 6 Big Ten showdown. The Ducks are coming off a dominant 34-13 win over UCLA at the Rose Bowl. Quarterback Dillon Gabriel threw for 278 yards and three touchdowns in the win. The Spartans are looking to bounce back from a 38-7 blowout loss at home to Ohio State. Michigan State is 2-3, while Oregon is 1-3 against the spread in 2024.

Kickoff in Eugene is scheduled for 9 p.m. ET. The Ducks are favored by 23.5 points in the latest Michigan State vs. Oregon odds via SportsLine consensus, while the over/under is 52 points. Before making any Oregon vs. Michigan State picks, you need to see the Week 6 college football predictions and betting advice from SportsLine’s Jimmie Kaylor. 

Kaylor is an NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years. 

Kaylor destroyed the books in college football in 2023, netting a whopping 57.9 units while posting a 107-45-2 record. Anyone who followed his picks finished the season way up.

Now, Kaylor has dialed in on Oregon vs. Michigan State on Friday and just revealed his picks and predictions. You can head to SportsLine now to see his picks. Here are the college football odds and betting lines on the spread, money line and over/under for Michigan State vs. Oregon:

• Oregon vs. Michigan State spread: Oregon -23.5
• Oregon vs. Michigan State over/under: 52.5 points 
• Oregon vs. Michigan State money line: Oregon -2439, Michigan State +1096
• Oregon vs. Michigan State picks: See picks at SportsLine
• Oregon vs. Michigan State streaming: FuboTV (Try for free)

Why Oregon can cover

Dan Lanning’s 2024 Ducks entered the season with many pundits saying they were the most talented team in program history. Oregon wasn’t sharp to open the season, but still managed to win all four games leading up to this matchup. The Ducks have played their two best games of the season leading up to Friday, notching dominant wins over Oregon State and UCLA in consecutive weeks.

Quarterback Dillon Gabriel is a game-changer in the Oregon offense. The former UCF and Oklahoma standout was immediately tabbed as a Heisman Trophy contender when he signed with the Ducks via the Transfer Portal this past offseason. Gabriel enters this game with 1,192 passing yards, nine touchdown passes, and one interception. He’s also rushed for 49 yards and two scores. See which team to pick here. 

Why Michigan State can cover

First-year Michigan State head coach Jonathan Smith is no stranger to the Ducks. Prior to landing the MSU job, Smith had served as the head coach at Oregon State for the last six seasons. During his time in Corvallis, Smith led the Beavers to a 2-4 record against Oregon, despite being sizable underdogs in each of those games. 

Michigan State quarterback Aidan Chiles followed Smith from Corvallis to East Lansing during the offseason. Chiles has been inconsistent to open the season, but his overall talent is undeniable. The sophomore quarterback was a four-star, national top-100 recruit coming out of high school, according to 247Sports. His running ability could present a significant problem for Oregon’s defense. See which team to pick here. 

How to make Michigan State vs. Oregon picks

Kaylor has analyzed Oregon vs. Michigan State from every angle and he’s leaning Over on the point total. He has also discovered a critical X-factor that has him jumping all over one side of the spread. He’s only sharing what it is, and which side to back, at SportsLine.

So who wins Michigan State vs. Oregon on Friday, and what critical X-factor makes one side of the spread a must back? Visit SportsLine now to see which side of the spread to jump on, all from the expert who profited $5,790 for $100 college football bettors in 2023, and find out.