The No. 1 Oregon Ducks (8-0, 5-0) put their perfect record on the line when they travel to Michigan Stadium to take on the Michigan Wolverines (5-3, 3-2) on Saturday. The Ducks have hit the ground running in their first season in the Big Ten, and will be looking to build off their dominant 38-9 win over Illinois last week. The Wolverines are looking to build off a 24-17 win over Michigan State in The Battle for the Paul Bunyan Trophy. Oregon quarterback Dillon Gabriel enters this matchup as the betting favorite to win the 2024 Heisman Trophy. The Ducks are 4-4 and the Wolverines are 2-6 against the spread this season. Cornerback Will Johnson (leg) is doubtful for Michigan.

Kickoff in Ann Arbor is scheduled for 3:30 p.m. ET. The Ducks are favored by 14 points in the latest Michigan vs. Oregon odds via SportsLine consensus, while the over/under is 45 points. Before making any Oregon vs. Michigan picks, you need to see the Week 10 college football predictions and betting advice from SportsLine’s Jimmie Kaylor. 

Kaylor is an NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big on sports betting apps for the last two years. 

Kaylor has destroyed the sportsbooks in college football the last two seasons, netting a whopping 71.1 units while posting a 191-112-3 record since Week 1 of the 2023 season. All of his picks have been featured on his SportsLine expert page or in his weekly bylined articles. Anyone who followed his picks is way up.

Now, Kaylor has dialed in on Oregon vs. Michigan on Saturday and just revealed his college football picks and predictions. You can head to SportsLine now to see his picks. Here are the college football odds and college football betting lines for Michigan vs. Oregon:

• Oregon vs. Michigan spread: Oregon -14
• Oregon vs. Michigan over/under: 45 points 
• Oregon vs. Michigan money line: Oregon -157, Michigan +131
• Oregon vs. Michigan picks: See picks at SportsLine
• Oregon vs. Michigan streaming: FuboTV (Try for free)

Why Oregon can cover

The 2024 Oregon team is widely considered to be the most talented team in program history. The Ducks have been dominant on both sides of the ball this season, and have been playing their best football recently. Dan Lanning’s team is 3-0 against the spread in its last three games, and is the top ranked team in the country. 

Quarterback Dillon Gabriel has found his groove, and now has a chance to become the second Heisman Trophy winner in program history. The former UCF and Oklahoma standout has thrown for 2,378 yards, 18 touchdowns, and five interceptions. He’s also rushed for 97 yards and five scores. Running back Jordan James ranks near the top of the Big Ten in rushing yards (800) and rushing touchdowns (8). See which team to pick here.

Why Michigan can cover

Michigan is only one year removed from a dominant national championship run, and several key players return from that team. Defensive tackles Mason Graham and Kenneth Grant form arguably the top interior defensive line duo in the country, and both will likely be early picks in the 2025 NFL Draft. 

Offensively, the Wolverines have had some inconsistency issues, but there is some optimism around quarterback Davis Warren, who was efficient in the team’s win over Michigan State. Michigan has an explosive 1-2 punch at running back in Kalel Mullings (694 yards, 7 touchdowns) and Donovan Edwards (415 yards, three touchdowns). Tight end Colston Loveland is arguably the best tight end in college football. See which team to pick here. 

How to make Michigan vs. Oregon picks

Kaylor has analyzed Oregon vs. Michigan from every angle and he’s leaning Under on the point total. He has also discovered a critical X-factor that has him jumping all over one side of the spread. He’s only sharing what it is, and which side to back, at SportsLine.

So who wins Oregon vs. Michigan in Ann Arbor on Saturday, and what critical X-factor makes one side of the spread a must back? Visit SportsLine now to see which side of the spread to jump on, all from the expert who profited $7,110 for $100 college football bettors since Week 1 of the 2023 season, and find out.