The No. 4 Ohio State Buckeyes (6-1, 3-1) hit the road looking to solidify their College Football Playoff resume when they travel to Happy Valley to take on the No. 3 Penn State Nittany Lions (7-0, 4-0) at Beaver Stadium on Saturday. The Buckeyes bounced back from their first loss of the season, beating Nebraska 21-17 last week. Penn State has been dominant in 2024, winning the bulk of its games in blowout fashion. In their last outing, the Nittany Lions beat Wisconsin 28-13 on the road. Both teams are 3-4 against the spread, and Ohio State leads the all-time series 24-14. Penn State quarterback Drew Allar (leg) is a game-time decision. 

Kickoff in Happy Valley is scheduled for noon ET. The Buckeyes are favored by 3 points in the latest Penn State vs. Ohio State odds via SportsLine consensus, while the over/under is 47.5 points. Before making any Ohio State vs. Penn State picks, you need to see the Week 10 college football predictions and betting advice from SportsLine’s Jimmie Kaylor. 

Kaylor is an NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big on sports betting apps for the last two years. 

Kaylor has destroyed the sportsbooks in college football the last two seasons, netting a whopping 71.1 units while posting a 191-112-3 record since Week 1 of the 2023 season. All of his picks have been featured on his SportsLine expert page or in his weekly bylined articles. Anyone who followed his picks is way up.

Now, Kaylor has dialed in on Ohio State vs. Penn State on Saturday and just revealed his college football picks and predictions. You can head to SportsLine now to see his picks. Here are the college football odds and college football betting lines for Penn State vs. Ohio State:

• Ohio State vs. Penn State spread: Ohio State -3
• Ohio State vs. Penn State over/under: 47.5 points 
• Ohio State vs. Penn State money line: Ohio State -162, Penn State +135
• Ohio State vs. Penn State picks: See picks at SportsLine
• Ohio State vs. Penn State streaming: FuboTV (Try for free)

Why Ohio State can cover

As has become the norm, Ohio State is once again armed with high-end talent and future NFL Draft picks. On the defensive side of the ball, the Buckeyes are led by defensive tackle Tyleik Williams and safety Caleb Downs. Williams is a massive interior presence, but still leads the team with 2.5 sacks. Downs, a transfer from Alabama, is an All-America candidate and might be the best safety in college football. 

Offensively, the Buckeyes are loaded at the wide receiver position. Freshman Jeremiah Smith leads the team with 623 yards and eight touchdowns. Senior Emeka Egbuka leads the team in receptions (43) to go along with 546 yards and six touchdowns. The duo will keep constant pressure on Penn State’s secondary. See which team to pick here. 

Why Penn State can cover

Penn State has been one of the most dominant teams in the country this season. Five of the Nittany Lions’ seven wins have come by double digits, and they rank near the top of the Big Ten in offense and defense. Penn State enters this matchup ranked fourth in the conference in points scored per game (33.3) and second in points allowed per game (14.3). 

Penn State has a slew of offensive weapons that should help them keep pace with the Buckeyes regardless of Allar’s status. Tight end Tyler Warren leads the team with 47 catches for 559 yards and four touchdowns. Running backs Kaytron Allen (509 yards, four touchdowns) and Nicholas Singleton (483 yards, three touchdowns) give the Nittany Lions a potent 1-2 punch out of the backfield. See which team to pick here. 

How to make Penn State vs. Ohio State picks

Kaylor has analyzed Ohio State vs. Penn State from every angle and he’s leaning Over on the point total. He has also discovered a critical X-factor that has him jumping all over one side of the spread. He’s only sharing what it is, and which side to back, at SportsLine.

So who wins Penn State vs. Ohio State in Happy Valley on Saturday, and what critical X-factor makes one side of the spread a must back? Visit SportsLine now to see which side of the spread to jump on, all from the expert who profited $7,110 for $100 college football bettors since Week 1 of the 2023 season, and find out.