The No. 4 Ohio State Buckeyes (5-1) will try to bounce back from their first loss of the season when they host the Nebraska Cornhuskers (5-2) on Saturday afternoon. Ohio State came up just short in a 32-31 loss at then-No. 3 Oregon two weeks ago, as the Ducks kicked a game-winning field goal with less than two minutes remaining. The Buckeyes had an extra week to prepare for this game following that loss, and now they will try to stay on track for a spot in the College Football Playoff. Nebraska is coming off its worst performance of the season, getting blasted by then-No. 16 Indiana in a 56-7 final. 

Kickoff is set for noon ET on Saturday at Ohio Stadium. Ohio State is favored by 25.5 points in the latest Ohio State vs. Nebraska odds, while the over/under is 48.5 points, per SportsLine consensus. Before entering any Nebraska vs. Ohio State picks, you’ll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it is a sizzling 14-7 on all top-rated picks over the past four weeks of this season. Anyone following at sportsbooks and on betting apps has seen strong returns.

The model has set its sights on Nebraska vs. Ohio State. You can head to SportsLine to see its picks. Here are several college football betting lines for the game:

• Ohio State vs. Nebraska spread: Ohio State -25.5
• Ohio State vs. Nebraska over/under: 48.5 points
• Ohio State vs. Nebraska money line: Ohio State -4762, Nebraska +1500
• Ohio State vs. Nebraska picks: See picks here
• Ohio State vs. Nebraska streaming: FuboTV (Try for free)

Why Ohio State can cover

Ohio State would likely be the top-ranked team in the country if it had held on to its late lead against Oregon two weeks ago, and it had an extra week to rest and prepare for this matchup. The Buckeyes are averaging 43.5 points per game this season, while their defense is giving up just 11.0 points per game. Senior quarterback Will Howard has completed 73.3% of his passes for 1,574 yards, 14 touchdowns and two interceptions. 

Junior running back Quinshon Judkins leads the rushing attack with 491 yards and six touchdowns, while senior TreVeyon Henderson has 424 yards and four scores. This series has been extremely lopsided in recent years, as Ohio State has won seven consecutive meetings and has covered the spread in six of the last eight matchups. The Buckeyes have covered the spread in seven of their last nine Saturday home games. See which team to pick here. 

Why Nebraska can cover

Nebraska is coming off easily its worst showing of the season, making this a buy-low spot. The Cornhuskers won five of their first six games this year, including blowout wins over Colorado and Purdue. Their only other loss came in overtime against then-No. 24 Illinois, so they have been a competitive team. 

Freshman quarterback Dylan Raiola has completed 66% of his passes for 1,579 yards and nine touchdowns, while sophomore running back Dante Dowdell has 350 yards and five scores. Ohio State is in a letdown spot following its loss to Oregon, especially since it has a road game at No. 3 Penn State coming up next week. The Cornhuskers covered the spread as 14-point home underdogs when these teams met last season. See which team to pick here. 

How to make Ohio State vs. Nebraska picks

The model has simulated Nebraska vs. Ohio State 10,000 times and the results are in. The model is leaning Over, and it’s also generated a point-spread pick that is hitting in over 60% of simulations. You can only see the pick at SportsLine.

So who wins Ohio State vs. Nebraska, and which side of the spread is hitting over 60% of the time? Visit SportsLine now to see which side of the Nebraska vs. Ohio State spread to jump on, all from the advanced computer model that’s up well over $2,000 on its top-rated college football spread picks since its inception, and find out.