Christian McCaffrey is active for the San Francisco 49ers for the first time this season. After what head coach Kyle Shanahan called an “awesome” performance at practice the past two days, McCaffrey will make his season debut against the Tampa Bay Buccaneers on Sunday. He was officially activated off injured reserve on Saturday.

McCaffrey has been out all season due to Achilles tendinitis and calf tightness, with trouble first coming when he was a late scratch in Week 1. He was soon placed on injured reserve, with a hazy timetable to return to the field.

He underwent treatment from a specialist in Germany in September and didn’t return to practice until this week. This week, he has been listed as a limited participant in practice.

With McCaffrey out, the 4-4 Niners have struggled to replicate their success from last season, due to both the running back’s absence and other factors. Jordan Mason has handled the bulk of running duties, posting 685 rushing yards and three touchdowns while averaging 5.1 yards per carry (McCaffrey averaged 5.4 yards last season).

Here are the inactives for Week 10. (Players will be added as teams release their reports.)

New England Patriots

• G Tyrese Robinson

• DE Yannick Ngakoue

• WR Tyquan Thornton

• S Kyle Dugger

• LB Christian Elliss

• DT Eric Johnson

• QB Joe Milton III

Chicago Bears

• DB Jaquan Brisker

• LB Noah Sewell

• OL Darnell Wright

• OL Braxton Jones

• DB Ameer Speed

• DL Darrell Taylor

• OL Nate Davis

• OL Kiran Amegadjie

Buffalo Bills

• WR Keon Coleman

• WR Amari Cooper

• FB Reggie Gilliam

• LB Edefuan Ulofoshio

• OL Will Clapp

• WR KJ Hamler

Indianapolis Colts

• QB Sam Ehlinger

• WR Anthony Gould

• WR Michael Pittman Jr.

• S Darren Hall

• DE Genard Avery

• DT Adam Gotsis

Denver Broncos

• QB Zach Wilson

• CB Kris Abrams-Draine

• DB Keidron Smith

• T Frank Crum

• G Calvin Throckmorton

• TE Greg Dulcich

• DL Eyioma Uwazurike

Kansas City Chiefs

• WR JuJu Smith-Schuster

• RB Clyde Edwards-Helaire

• OL C.J. Hanson

• T Ethan Driskell

• DT Marlon Tuipulotu

• DE Cameron Thomas

Atlanta Falcons

• RB Jase McClellan

• ILB JD Bertrand

• ILB Rashaan Evans

• DL Brandon Dorlus

• OL Jovaughn Gwyn

• OL Elijah Wilkinson

• T Brandon Parker

New Orleans Saints

• WR Cedrick Wilson

• CB Kool-Aid McKinstry

• QB Spencer Rattler

• RB Jamaal Williams

• LB Jaylan Ford

• G/C Lucas Patrick

• DT Khristian Boyd

San Francisco 49ers

• QB Joshua Dobbs

• WR Chris Conley

• DL Kevin Givens

• OL Ben Bartch

• CB Charvarius Ward

• TE Brayden Willis

Tampa Bay Buccaneers

• DL Earnest Brown

• TE Devin Culp

• WR Mike Evans

• LB Antonio Grier

• G Royce Newman

• OLB Jose Ramirez

• S Tykee Smith

Pittsburgh Steelers

• QB Kyle Allen

• WR Scott Miller

• CB C.J. Henderson

• LB Nick Herbig

• OG Max Scharping

Washington Commanders

• K Austin Seibert

• RB Brian Robinson Jr.

• QB Jeff Driskel (3rd QB)

• S Darrick Forrest

• CB Marshon Lattimore

• LB Dominique Hampton

• T Cornelius Lucas

Minnesota Vikings

• QB Brett Rypien

• CB Fabian Moreau

• CB Dwight McGlothern

• DL Levi Drake Rodriguez

• OL Dan Feeney

• T Walter Rouse

Jacksonville Jaguars

• QB Trevor Lawrence

• DE Myles Cole

• OL Ezra Cleveland

• DT Esezi Otomewo

• DT Maason Smith

Tennessee Titans

• CB L’Jarius Sneed (quad): out

• RB Julius Chestnut (foot): questionable

• T Dillon Radunz (toe): questionable

Los Angeles Chargers

• CB Kristian Fulton (hamstring): doubtful

• OLB Joey Bosa (hip): questionable

• RB Gus Edwards (ankle): questionable

• OLB Khalil Mack (groin): questionable

• LB Denzel Perryman (toe): questionable

• T Trey Pipkins (ankle): questionable

• TE Stone Smartt (ankle): questionable

Philadelphia Eagles

Dallas Cowboys

• QB Dak Prescott (hamstring): out

• CB DaRon Bland (foot): out

• S Juanyeh Thomas (concussion): out

• CB Trevon Diggs (calf, illness): questionable

• T Tyler Guyton (neck, shoulder): questionable

• LB Eric Kendricks (shoulder): questionable

• DE Micah Parsons (ankle): questionable

• LB Nick Vigil (foot): questionable

New York Jets

• RG Jake Hanson (hamstring): out

• LB C.J. Mosley (neck): out

• CB Michael Carter II (back): questionable

• OL Morgan Moses (knee): questionable

• DL Solomon Thomas (knee): questionable

• G Alijah Vera-Tucker (ankle/non-injury/personal): questionable

• LB Chazz Surratt (heel): questionable

• TE Tyler Conklin (ankle): questionable

Arizona Cardinals

• DT Darius Robinson (calf): out

• S Jalen Thompson (ankle): questionable

• T Jonah Williams (knee): questionable

Detroit Lions

• T Taylor Decker (shoulder): out

• DT Brodric Martin (knee): out

• LB Jalen Reeves-Maybin (neck): out

• S Ifeatu Melifonwu (ankle): out

• CB Emmanuel Moseley (pectoral): out

• LB Malcolm Rodriguez (ankle): out

• DE Za’Darius Smith (personal): questionable

Houston Texans

• DE Will Anderson Jr. (ankle): out

• RB Dameon Pierce (groin): out

• DT Foley Fatukasi (groin, shoulder): questionable

• LB Jake Hansen (ankle): questionable

• DE Jerry Hughes (hip): questionable

• CB Jeff Okudah (quad): questionable

• WR Tank Dell (back): questionable

• WR Nico Collins (hamstring): questionable

Miami Dolphins

• OL Austin Jackson (knee): out

• S Jevon Holland (hand/knee): questionable

• FB Alec Ingold (calf): questionable

• S Patrick McMorris (calf): questionable

• WR River Cracraft (shoulder): questionable

• WR Tyreek Hill (wrist): questionable

Los Angeles Rams

• OT Rob Havenstein (ankle): out

• DT Neville Gallimore (shoulder): out

• S Kam Curl (knee): questionable

• G Kevin Dotson (ankle/knee): questionable

• LB Christian Rozeboom (neck): questionable

New York Giants

• WR Darius Slayton

• S Jason Pinnock

• WR Bryce Ford-Wheaton

• LB Darius Muasau

• DL Jordon Riley

• OL Jake Kubas

• QB Tommy DeVito

Carolina Panthers

• S Jammie Robinson

• RB Jonathon Brooks

• CB Shemar Bartholomew

• OLB Charles Harris

• LT Ikem Ekwonu

• TE Tommy Tremble

• DT Jaden Crumedy