NFL Wild Card Weekend 2025 will conclude when the Los Angeles Rams take on the Minnesota Vikings at 8 p.m. ET on Monday Night Football. Wildfires in Southern California have moved this game from SoFi Stadium to State Farm Stadium in Glendale, Ariz. The Vikings are 2.5-point favorites despite losing to the Rams on the road earlier this season. How will the rematch unfold, and who are the best options in the NFL DFS player pool for MNF? Wide receiver, in particular, is loaded for this single-game slate, with Puka Nacua, Justin Jefferson, Cooper Kupp and Jordan Addison all producing multiple week-winning performances in NFL daily Fantasy throughout the year. Before locking in any NFL DFS picks on sites like DraftKings and FanDuel for Vikings vs. Rams on Monday in the 2025 NFL playoffs, be sure to check out the NFL DFS advice, strategy, and stacks from SportsLine daily Fantasy expert Mike McClure. 

McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings. Last year, he won the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him could be way up.

Now, McClure has turned his attention to Wild Card Weekend on Monday and just locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine.

Top NFL DFS picks for Vikings vs. Rams

One of McClure’s top NFL DFS picks for Monday Night Football is Rams running back Kyren Williams. After playing sparingly on offense during his rookie season, Williams broke through with 1,350 scrimmage yards and 15 touchdowns in only 12 games in 2023 and further established himself as one of the most productive backs in the NFL in 2024.

He rushed for 1,299 yards and 14 touchdowns while adding 34 catches for 182 yards and two more scores this season. He scored a touchdown in 12 of the 16 games that he played in 2024 and had seven outings where he piled up at least 100 scrimmage yards. His reliable workload in scoring areas alone makes him worth heavy exposure, but he also had 97 rushing yards in a win over Minnesota on Oct. 24. See who else to roster here.

McClure’s optimal NFL DFS strategy also involves rostering Vikings wide receiver Justin Jefferson. For the third time in his career, Jefferson reached 100 catches and 1,500 receiving yards in a season, becoming just the fifth player in NFL history to accomplish that feat. He also tied a career-high with 10 touchdown receptions and was selected to his fourth Pro Bowl.

The fifth-year pro has already piled up 495 catches for 7,432 yards and 40 touchdowns in his career and he’s reached at least 1,000 yards in all five seasons of his career. Against the Rams on Oct. 24, he had eight catches for 115 yards, which was his second of five 100-yard receiving games for the season. See who else to roster here.

How to set NFL DFS lineups for Rams vs. Vikings

McClure is targeting another undervalued player who could explode for huge numbers on Monday. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of McClure’s NFL DFS picks, at SportsLine.

So who is Mike McClure including in his optimal NFL DFS lineups for Monday Night Football in the 2025 NFL playoffs, and which under-the-radar player offers huge value? Visit SportsLine now to see optimal NFL DFS picks, NFL DFS rankings, NFL DFS advice and NFL DFS stacks, all from a daily Fantasy expert with more than $2 million in winnings, and find out.