The Arizona Wildcats (3-3, 1-2) are set to host Deion Sanders and the Colorado Buffaloes (4-2, 2-1) in a Big 12 matchup on Saturday. The Wildcats have gotten off to a disappointing start to the 2024 season, and will be looking to bounce back from their 41-19 blowout loss to BYU in Week 7. The Buffs lost 31-28 to Kansas State in their last outing, despite getting 388 yards and three touchdowns from quarterback Shedeur Sanders. Travis Hunter (shoulder) is expected to play for CU.

Kickoff at Arizona Stadium is at 4 p.m. ET. The Wildcats are 2.5-point favorites in the latest Colorado vs. Arizona odds via SportsLine consensus, and the over/under is 58 points. Before making any Arizona vs. Colorado picks, you need to see the Week 8 college football predictions and betting advice from SportsLine’s Jimmie Kaylor. 

Kaylor is an NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big on sports betting apps for the last two years. 

Kaylor has destroyed the sportsbooks in college football the last two seasons, netting a whopping 53.9 units while posting a 163-102-2 record since Week 1 of the 2023 season. Anyone who followed his picks finished the season way up.

Now, Kaylor has dialed in on Colorado vs. Arizona on Saturday and just revealed his picks and predictions. You can head to SportsLine now to see his picks. Here are the college football odds and college football betting lines for Arizona vs. Colorado:

• Colorado vs. Arizona spread: Arizona -2.5
• Colorado vs. Arizona over/under: 58 points 
• Colorado vs. Arizona money line: Arizona -132, Colorado +110
• Colorado vs. Arizona picks: See picks at SportsLine
• Colorado vs. Arizona streaming: FuboTV (try for free)

Why Arizona can cover

The Wildcats are a talented team that has underachieved in 2024. Arizona was picked by many experts to be one of the top teams in the Big 12 in its first season in the conference. With their high-end talent at key positions, the Wildcats are a team that can beat most teams in the country when they play well and take care of the ball.

Wide receiver Tetairoa McMillan is an absolute force that can single-handedly change games. The 6-foot-5 junior enters Saturday with 42 catches for 742 yards and four touchdowns. Against New Mexico on Aug. 31, McMillan caught 10 passes for 304 yards and four touchdowns. See which team to pick here.

Why Colorado can cover

The Buffs have been strong against the spread this season, going 4-2 overall and 2-1 in road games. Colorado has improved on both sides of the ball in Coach Prime’s second year on the job. Offensively, the Buffs have one of the Big 12’s best passing attacks led by quarterback Shedeur Sanders, and defensively they are allowing 24.3 points per game.

Sanders has thrown for 2,018 yards, 17 touchdowns and four interceptions this season. CU has a deep and extremely talented group of wide receivers, with four players with 318 or more receiving yards in 2024. Hunter leads the way with 49 catches for 587 yards and six touchdowns. See which team to pick here.

How to make Arizona vs. Colorado picks

Kaylor has analyzed Colorado vs. Arizona from every angle and he’s leaning Over on the point total. He has also discovered a critical X-factor that has him jumping all over one side of the spread. He’s only sharing what it is, and which side to back, at SportsLine.

So who wins Colorado vs. Arizona on Saturday in Tucson, and what critical X-factor makes one side of the spread a must back? Visit SportsLine now to see which side of the spread to jump on, all from the expert who has profited $5,390 for $100 college football bettors since Week 1 of the 2023 season, and find out.