We’ve got another exciting interconference contest on Wednesday’s NBA schedule as the Los Angeles Clippers will host the Detroit Pistons. Los Angeles is 32-29 overall and 19-10 at home, while Detroit is 35-27 overall and 18-13 on the road. The Pistons defeated the Clippers, 106-97, in Detroit on Feb. 24 in their first meeting of the season. Kawhi Leonard (rest) and Norman Powell (hamstring) are out for the Clippers, and Tobias Harris (personal) is out for the Pistons. 

Tipoff is set for 10:30 p.m. ET from the Intuit Dome in Inglewood, Calif. Detroit is favored by 4.5 points in the latest Pistons vs. Clippers odds, according to the SportsLine consensus. The over/under is 219.5 points. Before entering any Clippers vs. Pistons picks, you’ll want to see the NBA predictions from the model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters Week 20 of the 2024-25 NBA season on a sizzling 147-107 roll on all top-rated NBA picks dating back to last season, returning nearly $4,000. It’s also an outstanding 18-10 (64%) on top-rated spread picks this season. Anyone following at sportsbooks and on betting apps could have seen huge returns.

The model has set its sights on Los Angeles vs. Detroit. You can head to SportsLine to see its picks. Here are several NBA betting lines for Pistons vs. Clippers:

• Clippers vs. Pistons spread: Pistons -4.5
• Clippers vs. Pistons over/under: 219.5 points
• Clippers vs. Pistons money line: Pistons -195, Clippers +162
• DET: The Pistons are 8-2 against the spread (ATS) as a road favorite
• LAC: The Clippers are 20-9 ATS at home
• Clippers vs. Pistons picks: See picks at SportsLine
• Clippers vs. Pistons streaming: FuboTV (Try for free)

Why the Pistons can cover

The Pistons are one of the hottest teams in the league, entering 10-1 over their last 11 games. Detroit is coming off a 134-106 victory over the Jazz on Monday to start a four-game West Coast road trip. The Pistons have no issues being away from Detroit with the second-best ATS record (20-10-1, 66.7%) on the road this season. They’ve been even better under the expectations of winning with an 8-2 ATS record as the road favorite. The Pistons have covered the spread in eight of their last nine games, and their recent stretch has them up to the No. 6 seed and one game out of the No. 4 seed in the Eastern Conference.

Cade Cunningham had 29 points and nine assists against the Jazz as he’s 11th in the league in scoring (25.3 ppg) and third in assists (9.4 per game). Many expected the Pistons to be improved this season, but they’ve made a significant leap, and Detroit is 11th in the league in scoring (114.7 ppg) and shooting percentage (47.5%) to fuel the turnaround. The Clippers will also be without two of their top three leading scorers with Leonard (rest) and Powell (hamstring) out. See which team to pick here.

Why the Clippers can cover

James Harden is averaging 21.6 points and 8.6 assists per game as the Clippers will rely heavily on the 35-year-old guard on Wednesday. He had 21 points and 15 assists in a 119-117 loss to the Suns on Tuesday following a fourth quarter the Clippers will want to forget about. Los Angeles dominated the majority of the contest but was outscored 43-22 in the fourth quarter.

Ivica Zubac had 35 points on 15 of 19 shooting with 10 rebounds on Tuesday. The Clippers have the best home ATS record (20-9, 69%) in the league this season and have covered the spread in back-to-back home games. The team returns to Los Angeles off an eight-game road trip, and after dropping the final three on the road, this could be an entirely different Clippers performance back at the Intuit Dome. See which team to pick here.

How to make Clippers vs. Pistons picks

The model has simulated Pistons vs. Clippers 10,000 times and the results are in. The model is leaning Under, projecting 219 combined points, and it also says one side of the spread has better value. You can only see the pick at SportsLine.

So who wins Pistons vs. Clippers, and which side of the spread has better value? Visit SportsLine now to see which side of the Clippers vs. Pistons spread you need to jump on, all from the model that is on a 147-107 roll on top-rated NBA picks since last season, and find out.

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