The Detroit Pistons are set to host the Boston Celtics in an Eastern Conference matchup on Wednesday at Little Caesars Arena. Detroit is 32-26 overall and 15-13 at home, while Boston is 42-16 overall and 24-6 on the road. Both teams are riding lengthy winning streaks. Detroit has won seven straight games, and is looking to build off its 106-97 win over the Los Angeles Clippers on Monday. Boston has won six straight, after beating the Toronto Raptors 111-101 on Tuesday. The Pistons are 33-24-1 and the Celtics are 26-32 against the spread this season. Jaylen Brown (thigh) is questionable for Boston.

Tipoff in Detroit is at 7 p.m. ET. The Celtics are favored by 5 points in the latest Pistons vs. Celtics odds via SportsLine consensus, and the over/under is 226.5 points. Before locking in any Pistons vs. Celtics picks, you’ll want to see the NBA predictions and betting advice from the proven computer simulation model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters Week 19 of the 2024-25 NBA season on a sizzling 147-106 roll on all top-rated NBA picks dating back to last season, returning nearly $4,000. It’s also an outstanding 18-10 (64%) on top-rated spread picks this season. Anyone following at sportsbooks and on betting apps could have seen huge returns.

The model has set its sights on Boston vs. Detroit and just locked in its picks and NBA predictions. You can head to SportsLine now to see the model’s picks. Here are several NBA betting lines for the game:

• Pistons vs. Celtics spread: Boston -5
• Pistons vs. Celtics over/under: 226.5 points
• Pistons vs. Celtics money line: Boston -195, Detroit +163
• Pistons vs. Celtics picks: See picks at SportsLine
• Pistons vs. Celtics streaming: FuboTV (Try for free)

Why the Pistons can cover

The Celtics are hoping to do what the Clippers couldn’t on Monday: put an end to the Pistons’ winning streak, which now stands at seven games. The Pistons came out on top against the Clippers by a score of 106-97. The Pistons can attribute much of their success to Cade Cunningham, who almost dropped a double-double on 32 points and nine rebounds. 

Cunningham has now scored at least 30 points in four straight games. The former No. 1 overall pick enters Wednesday averaging 25.8 points, 9.5 assists, and 6.5 rebounds per game. Center Jalen Duren is averaging a double-double for Detroit with per game averages of 11.1 points and 10.3 rebounds. See which team to pick here.

Why the Pistons can cover

Meanwhile, the Celtics entered their contest with the Raptors on Tuesday with five consecutive wins but they’ll enter their next game with six. They cruised to a 111-101 victory over Toronto. The Celtics’ win was a true team effort, with many players turning in solid performances. Perhaps the best among them was Derrick White, who went 6 for 11 from beyond the arc en route to 22 points plus five assists and three steals. 

The Celtics once again look like one of the top contenders in the Eastern Conference. Boston currently sits in second place, trailing only the Cleveland Cavaliers. Six-time NBA All-Star Jayson Tatum leads the way for the Celtics averaging 26.6 points, 8.7 rebounds, and 5.8 assists per game. See which team to pick here.

How to make Pistons vs. Celtics picks

The model has simulated Pistons vs. Celtics 10,000 times and the results are in. We can tell you that the model is leaning Under on the point total, and it’s also generated a point-spread pick that is hitting in nearly 60% of simulations. You can only see the model’s pick at SportsLine.

So who wins Pistons vs. Celtics, and which side of the spread hits nearly 60% of the time? Visit SportsLine now to see which side of the Celtics vs. Pistons spread you need to jump on, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out. 

Where to bet on NBA games

Here are some of the sportsbooks to bet on NBA games today, along with the various NBA sportsbook promos they currently offer.