Two weeks remain in major college football’s regular season, and the latest Game of the Season in the Big Ten will play out in Columbus, Ohio, on Saturday, when No. 2 Ohio State faces No. 5 Indiana in a game heavy with College Football Playoff implications. Elsewhere in the Big Ten, Michigan, Nebraska, USC and Wisconsin seek their sixth win to secure a bowl berth. (All games Saturday unless designated. The Gophers-Penn State prediction will run later this week.)

No. 5 Indiana at No. 2 Ohio State, 11 a.m., Fox

• Will the clock strike midnight for Cinderella? Maybe, but if the Hoosiers are competitive against the Buckeyes, a loss likely won’t cost them a spot in the playoff. Ohio State takes a step closer to a rematch with Oregon for the Big Ten title. Ohio State 34, Indiana 23

Wisconsin at Nebraska, 2:30 p.m., BTN

• The Huskers turned over their offensive keys to Mike Leach disciple Dana Holgorsen last week, and the Badgers fired offensive coordinator Phil Longo on Sunday. Wisconsin has a 10-game winning streak vs. Nebraska, but the Huskers end that skid and secure a bowl trip for the first time since 2016. Nebraska 24, Wisconsin 20

USC at UCLA, 9:30 p.m., NBC

• The Trojans and Bruins have split the past dozen games between the former Pac-12 powers. UCLA needs wins over USC and Fresno State to reach a bowl game, while USC must beat either UCLA or Notre Dame. UCLA 27, USC 24

Iowa at Maryland, 11 a.m., BTN