Fans will be treated to several mouthwatering NFL matchups to bet on this week. Week 10 of the 2024 NFL schedule is jam-packed with star-studded showdowns, including Broncos vs. Chiefs (-7.5, 41.5), Eagles vs. Cowboys (+7, 43), and Lions vs. Texans (+3.5, 49). The Week 10 NFL schedule wraps up on Monday Night Football when Matthew Stafford and the Los Angeles Rams host Tua Tagovailoa and the Miami Dolphins. The latest Week 10 NFL odds via the SportsLine Consensus list the Rams as one-point home favorites.

The Steelers, meanwhile, will enter their road tilt against the Commanders as three-point underdogs according to the latest Week 10 NFL betting lines. Making NFL score predictions on all 14 Week 10 games can help form not only NFL spread picks, but also NFL over/under picks, NFL parlay picks, NFL office pool picks, and NFL survivor picks. Which Week 10 NFL games will be lopsided, and which ones will play out closer to their NFL spreads? Before you make any Week 10 NFL picks, make sure you see what SportsLine’s advanced computer model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 of the 2024 NFL season on an incredible 14-7 betting hot streak on top-rated NFL picks this year. Longer term, it is on a 195-136 roll on top-rated NFL picks that dates back to the 2017 season and a 49-29 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone following at sportsbooks and on betting apps has seen strong returns at their best sports betting app.

Now, the model has simulated every Week 10 game 10,000 times. You can only see the model’s Week 10 NFL exact score predictions at SportsLine.

Top Week 10 NFL picks

After diving into every game on the Week 10 NFL schedule, the model is backing the Los Angeles Chargers (-7.5, 38.5) to beat the Tennessee Titans, 26-16, at home. The Chargers have won three of their past four games and enter Sunday’s showdown with the NFL’s top-ranked scoring defense, allowing just 12.6 points per game. The Titans, meanwhile, are averaging only 17.5 points per game, which ranks 27th in the league. 

The Chargers have also won eight consecutive home games against the Titans. In addition, Tennessee is 2-13 over its past 15 games on the road. SportsLine’s model is projecting Chargers quarterback Justin Herbert to throw for 222 yards and two touchdowns, while Los Angeles’ defense records three sacks on average. See the model’s other Week 10 NFL score predictions at SportsLine.

How to make Week 10 NFL score predictions

In addition, the model has locked in exact score predictions for this week’s biggest matchups including Lions vs. Texans, Eagles vs. Cowboys and Steelers vs. Commanders. It’s also calling for a surprising underdog to pull off a shocking upset, making this team a must-back. Nailing this result is key to making profitable Week 10 NFL picks. You can only see them at SportsLine. 

Who wins each Week 10 NFL game, and which surprising underdog pulls off a shocking upset? Visit SportsLine now to get the model’s NFL Week 10 score predictions, all from the model on a 195-136 roll on top-rated NFL picks, and find out.