The Week 7 college football schedule has arrived and there are plenty of must-see matchups set to unfold on Saturday. One of the most intriguing matchups of the day happens in the Big Ten when No. 3 Oregon hosts No. 2 Ohio State at 7:30 p.m. ET. The Buckeyes feature college football’s stingiest defense, giving up just 6.80 points per game, while the Ducks are averaging 35.0 points per game offensively. The latest Week 7 college football odds via SportsLine consensus list the Buckeyes as 3-point favorites on the road.

Other Week 7 college football lines of note include No. 1 Texas vs. No. 18 Oklahoma (+14), No. 4 Penn State vs. USC (+3.5) (3:30 p.m. ET, CBS) and No. 9 Ole Miss vs. No. 13 LSU (+3.5). Which games should you target for Week 7 college football bets? Before locking in any Week 7 college football picks on those games or others, be sure to see the college football betting guide from legendary Vegas handicapper Bruce Marshall. 

For years Vegas-based Marshall was synonymous with The Gold Sheet, the famed sports betting newsletter. With a background in play-by-play work and sports information while in college, Marshall joined TGS in 1981 when hired by the legendary Mort Olshan and served as executive editor for many years. 

An in-demand guest on numerous sports talk radio and TV shows across the country, Bruce’s vast array of editorial work has been featured in the Las Vegas Review-Journal, the New York Post and many other outlets. He has won various handicapping titles and also is working on several book projects. Bruce also enters the Week 7 college football schedule on an 18-8 roll (+899) on his official SportsLine college football spread picks. 

Now, using his Tech Corner technique that evaluates all the trends and the latest college football odds, Marshall has turned his attention to college football betting for Week 7 and revealed picks for each matchup. Head to SportsLine to see every pick.

Top college football predictions for Week 7

One of the top college football picks Marshall is recommending for Week 7: He’s backing No. 7 Alabama (-21.5) to cover against South Carolina as the Tide return home for a noon ET matchup on Saturday. Alabama’s offense has been prolific this season, averaging 44.6 points per game, which ranks eighth in the nation. 

Quarterback Jalen Milroe has been extremely effective, throwing for 1,274 yards, 11 touchdowns and two interceptions. He’s also recorded 59 carries for 283 yards and nine rushing touchdowns. Even in last week’s loss to Vanderbilt, Milroe completed 18 of 24 pass attempts for 310 yards, one touchdown and one interception.

The Crimson Tide are 8-0 in their last eight games at home and they’re 11-5 against the spread in their past 16 games overall. The Gamecocks, meanwhile, are just 6-7 ATS as a road underdog with head coach Shane Beamer at the helm.

Marshall is also taking the Over (50.5) in this matchup since the total has gone over in five of Alabama’s last seven games against South Carolina. See which other picks to make here. 

How to make college football picks for Week 7

Marshall has evaluated every other matchup and he’s found an alarming 8-0 betting trend you need to know this week. Get betting analysis for each matchup at SportsLine.

So what college football picks can you make with confidence, and what alarming trend do you need to know about? Check out the latest college football odds below, then visit SportsLine to see which teams to back, all from the legendary Vegas expert who has won multiple handicapping titles, and find out.

Week 7 college football odds 

See full Week 7 college football picks, odds and predictions here.

Friday, Oct. 11

Northwestern at Maryland (-10.5, 45.5)

UNLV at Utah State (+18.5, 66.5)

Utah at Arizona State (+5.5, 46.5)

Saturday, Oct. 12

Clemson at Wake Forest (+20.5, 61.5)

South Carolina at Alabama (-21.5, 50.5)

Stanford at Notre Dame (-23.5, 45.5)

Texas vs. Oklahoma (+14, 48.5)

Penn State at USC (+3.5, 50.5)

Mississippi State at Georgia (-33.5, 54.5)

Florida at Tennessee (-14, 57)

Ole Miss at LSU (+3.5, 62.5)

Ohio State at Oregon (+3, 53.5)

Iowa State at West Virginia (+3.5, 53)

Kansas State at Colorado (+3.5, 56.5)