The Denver Broncos (3-3) and New Orleans Saints (2-4) will meet on Thursday Night Football to kick off the Week 7 NFL schedule. The Broncos had their three-game win streak put to an end last Sunday after they lost to the Chargers, 23-16. Meanwhile, the Saints have lost four games in a row after starting the season off 2-0. In Week 6, the Tampa Bay Buccaneers dominated New Orleans, 51-27. Quarterbck Derek Carr (oblique) is expected to remain out for the Saints, while receivers Chris Olave (concussion) and Rashid Shaheed (concussion) will be sidelined.

Kickoff from Caesars Superdome in New Orleans is set for 8:15 p.m. ET. Denver is a 2.5-point favorite in the latest Broncos vs. Saints odds, while the over/under for total points scored is 37. The Broncos are -147 money-line favorites, while the Saints are +125 underdogs. Before locking in any Saints vs. Broncos picks, make sure to check out the NFL predictions and betting advice from the SportsLine expert Matt Severance, considering his mastery of picks involving Denver.

Severance is a well-connected writer and high-volume handicapper who has worked in the industry since 2005. He went 121-93-2 for a profit of $589 on his NFL picks last season. Furthermore, Severance is on a 21-6 roll (+1371) on his last 27 Broncos picks. Anyone who has followed his betting picks is way up.

Now, Severance has locked in on Broncos vs. Saints and just revealed his coveted NFL picks and predictions. You can head to SportsLine now to see his picks. Here are several NFL odds and NFL betting lines for Saints vs. Broncos.

• Broncos vs. Saints spread: Denver -2.5
• Broncos vs. Saints over/under: 37 points
• Broncos vs. Saints money line: New Orleans +125, Denver -147
• DEN: Broncos are 4-2 against the spread
• NO: New Orleans is 3-3 ATS this season
• Broncos vs. Saints picks: See picks at SportsLine

Why the Saints can cover

Running back Alvin Kamara is one of the most dynamic playmakers in the NFL. Kamara has reliable hands as a pass-catcher, while using his vision to find the open crease. He’s fourth in the NFL in carries (104), seventh in rushing yards (428) and tied for second in rushing touchdowns (6).

The 29-year-old also has 28 receptions (36 targets) for 238 yards and one score. Kamara has four games with 100-plus scrimmage yards already this season. See who to back at SportsLine.

Why the Broncos can cover

The Broncos have one of the best defensive units in the league. Denver is fourth in the league in total defense (284.3) and scoring defense (16) as well as fifth in pass defense (170.2). Linebacker Jonathon Cooper has the relentlessness to track down quarterbacks. The Ohio State product has 25 total tackles with a team-best 4.5 sacks and four TFLs. 

Defensive end Zach Allen is disciplined and owns a quick first step. Allen has 29 stops, with a team-high 9 TFLs and 3.5 sacks. Cornerback Riley Moss has played at a high level in the secondary. Moss plays the position technically sound and is very active in run support. The Iowa product is second on the team in total tackles (39) with five pass breakups and one interception. See who to back at SportsLine.

How to make Broncos vs. Saints picks

Severance has analyzed Broncos vs. Saints from every possible angle, and while we can tell you he’s leaning Under the total, he has also discovered a critical X-factor that has him jumping all over one side of the spread. Find out what it is, and which team to back, at SportsLine. 

So who wins Broncos vs. Saints on Thursday Night Football, and what critical x-factor makes one side of the spread hit hard? Visit SportsLine now to see which side of the Broncos vs. Saints spread to back, all from the expert who is 21-6 on picks involving Denver, and find out.