Fiorentina seek their first win of the season with Moise Kean and Robin Gosens, while Tijjani Noslin steps in for injured Lazio striker Taty Castellanos.
It kicks off at the Stadio Franchi at 11.30 UK time (10.30 GMT).
The Viola are still looking for their first victory under Raffaele Palladino, after five draws between Serie A and the Conference League, plus last week’s 3-2 loss to Atalanta.
It is finally a full squad at his disposal, as ex-Genoa forward Albert Gudmundsson has shaken off a muscular issue, but is only on the bench and still waiting for his debut.
Former Lazio midfielder Danilo Cataldi faces his old club with David De Gea in goal, while Marin Pongracic is out of action.
The Biancocelesti had a better start under new coach Marco Baroni, picking up two wins, a draw and one defeat.
Castellanos is out with an adductor issue, while Samuel Gigot hurt his shoulder, so Noslin goes into the centre-forward role supported by Boulaye Dia and Mattia Zaccagni.
Gaetano Castrovilli left Fiorentina as a free agent this summer, so he returns to the Stadio Artemio Franchi as an opponent.
Fiorentina: De Gea; Martinez Quarta, Comuzzo, Biraghi; Dodò, Mandragora, Cataldi, Bove, Gosens; Colpani; Kean
Lazio: Provedel; Lazzari, Patric, Gila, Tavares; Guendouzi, Castrovilli; Isaksen, Dia, Zaccagni; Noslin
Veteran guard Alex Cappa is hitting the open market ahead of the start of the new league year. The Bengals announced that t
The 2025 NCAA Men's Basketball Tournament tips off with Selection Sunday on March 16, followed by the First Four games on March 18-19 at UD Arena in Dayton,
There wasn't a general consensus across the board with a league as stacked with talent as SEC women's basketball, but one thing the USA TODAY Sports Network vot
Argentina have named Tottenham defender Cristian Romero in their forthcoming squad for World Cup qualifiers against Uruguay and Brazil.The 26-year-old has not f