Napoli look to Romelu Lukaku, Giacomo Raspadori and Scott McTominay for their difficult trip to Como, where Nico Paz and Assane Diao lead the way.
It kicks off at the Stadio Sinigaglia at 11.30 GMT.
Inter beat Genoa 1-0 last night to temporarily go top of the table, so the pressure is on the Partenopei to end their run of three consecutive stalemates.
It is particularly crucial considering next weekend they have the Scudetto showdown with Inter.
David Neres and Pasquale Mazzocchi are out injured, but Leonardo Spinazzola has recovered enough to start on the left, with Matias Olivera still not at 100 per cent.
Antonio Conte continues with the 3-5-2 formation, using Matteo Politano as a right-sided winger, with Lukaku and Raspadori upfront.
Andre-Frank Zambo Anguissa also misses out, and is replaced by AFC Bournemouth loanee Philip Billing, who will make his Serie A debut against Como.
Como had lost three on the bounce until their surprise 2-0 victory away to Fiorentina.
Sergi Roberto, Ivan Azon, Ignace van der Brempt and Dele Alli are still out of action, joined by Alberto Dossena on the treatment table, but Alieu Fadera returns from suspension.
It is Assane Diao who has been most impressive since his January arrival, who along with starlet Nico Paz and Gabriel Strefezza leads the attack.
Como (4-3-2-1): Butez; Smolcic, Goldaniga, Kempf, Valle; Da Cunha, Perrone, Caqueret, Nico Paz, Strefezza; Diao.
Napoli (3-5-2): Meret; Di Lorenzo, Rrahmani, Buongiorno; Politano, Billing, Lobotka, McTominay, Spinazzola; Lukaku, Raspadori.
Serie A Liveblog: Como-Napoli, Cagliari-Juventus, Verona-Fiorentina, Empoli-Atalanta
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