The 2025 NFL Playoffs are upon us and NFL Wild Card Weekend and the expansion of the NFL playoff bracket has gifted us with six games on the NFL schedule during the first round. Texans vs. Chargers (-3) and Ravens vs. Steelers (+9.5) will take place on Saturday, while Bills vs. Broncos (+8.5), Eagles vs. Packers (+4.5), and Buccaneers vs. Commanders (+3) will be played on Sunday. The week’s action wraps up with Rams vs. Vikings (-1.5) on Monday Night Football. 

Despite playing in a rivalry matchup, the Ravens (-9.5) are the largest favorites in the NFL Wild Card Weekend odds. Who should you back in those games with playoff implications and how should you handle all your NFL money line, NFL over-under and NFL against the spread spread picks? Before you make any Wild Card Weekend NFL picks and postseason NFL score predictions, you need to see the NFL against the spread, NFL over-under, and NFL money line predictions powered by the self-learning SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine’s Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team’s historical data and then quantitatively evaluating the strength of the opponent’s defense by assigning a numeric value out of 100 called a matchup score.

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine’s AI PickBot has hit a whopping 2,131 4.5- and 5-star prop picks since the start of last season.

For Wild Card Weekend NFL betting, the AI PickBot has evaluated the NFL odds and provided NFL betting picks for all six games. You can only see the AI predictions for 2025 NFL Wild Card Weekend here.

Top NFL Wild Card Weekend AI picks

After analyzing every game during NFL Wild Card Weekend 2025, the AI PickBot says the Rams cover comfortably as 1.5-point home underdogs against the Vikings on Monday. The Vikings had the NFC North and home-field advantage in the NFC on the table for the taking, but came up well short of expectation in a 31-9 loss to the Lions in Week 18 that knocked them back into a wild card spot.

Now Minnesota has to go to Los Angeles, where the Vikings already lost earlier in the season. The Rams outgained them by 110 yards in a 30-20 win in Week 8 during a stretch where Los Angeles won nine of 11. Matthew Stafford threw for 279 yards and four touchdowns in the victory while rookie Jared Verse had 1.5 sacks and Byron Murphy recorded a late safety to help seal the win.

With the Vikings coming off the disappointment of the loss to Detroit, the Rams will undoubtedly attempt to follow the Lions’ blueprint in limiting Sam Darnold to 18-of-41 passing. The AI PickBot rates a Rams cover as an A+ pick and also predicts a 31-22 outright win on average. See its other NFL Wild Card Weekend score predictions and football picks at SportsLine.

How to make NFL Wild Card Weekend predictions

In addition, the AI PickBot has generated six highly-coveted A+ picks for NFL Wild Card Weekend 2025. You need to see the AI PickBot’s NFL picks before making any NFL Wild Card Weekend bets of your own. You can only see them at SportsLine.

Who wins and covers each NFL Wild Card Weekend game, and which A+ picks should you target now? Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the self-learning SportsLine AI PickBot that has nailed 2,131 top-rated picks since the start of last season.