With Week 6 of the 2024 NFL schedule featuring the first teams coming off byes, how should rest factor into making Week 6 NFL bets? The Lions, Titans, Eagles and Chargers were the first teams to have their bye last week, and the rested Eagles are the largest favorites in the latest Week 6 NFL odds. Philadelphia is a 9.5-point favorite over the Cleveland Browns, according to the latest Week 6 NFL odds and up almost a touchdown from the opener, so how should that affect your Week 6 NFL predictions?

The Buccaneers are 3.5-point favorites against the Saints in the latest Week 6 NFL spreads after Tampa Bay played last Thursday, and the Saints will be without quarterback Derek Carr (oblique). Can you trust rookie quarterback Spencer Rattler and the Saints on a shorter week with your NFL score predictions? Before you make any Week 6 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by the self-learning SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine’s Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team’s historical data and then quantitatively evaluating the strength of the opponent’s defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine’s AI PickBot has nailed 128 4-star picks or better this season and hit a whopping 1,674 4.5- and 5-star prop picks last season. Anyone who has followed it is way up.

For Week 6 NFL betting, the AI PickBot has evaluated the NFL odds and provided NFL betting predictions for all 14 games. You can only see the AI predictions for the Week 6 NFL schedule here.

Top Week 6 NFL AI picks

After analyzing every game in Week 6, the AI PickBot says the Broncos cover as 3-point home underdogs against the Chargers in  a game with the lowest over-under of the week, 35.5. Denver has won three straight games, including two road victories over the Buccaneers and Jets as two teams with high expectations entering the season, and had a dominant 34-18 win over the Raiders last week. Although the Chargers should be rested coming off a bye, Denver is playing significantly better football than many people expected entering the season, led by a top defense.

The Broncos have the No. 2 scoring defense in the NFL, allowing 14.6 points on the third-fewest yards (271.2) in the league this season. They are allowing the second-fewest yards per play (4.4) this season and the Chargers certainly haven’t been an offensive juggernaut under Jim Harbaugh. The Chargers rank 28th in total points at 17 points per game but they are 2-2 behind a strong defense of their own, allowing 12.5 ppg this season, which leads the league. The Broncos are averaging 23.3 ppg over their last three games and Bo Nix appears to be getting more comfortable in the offense, which is a main reason why the AI PickBot expects the Broncos to upset the Chargers and win outright with a score prediction of 20-18. See its other Week 6 football predictions and football picks at SportsLine.

How to make Week 6 NFL picks

In addition, the AI PickBot has generated 14 other A-rated picks for Week 6, including two with a coveted A+ grade. You need to see the AI PickBot’s NFL picks before making any Week 6 NFL bets of your own. You can only see them at SportsLine.

Who wins and covers each Week 6 NFL game, and which A+ picks should you target now? Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that has nailed 128 top-rated picks this season.