The No. 4 Ohio State Buckeyes (5-1) will try to get back on track when they host the Nebraska Cornhuskers (5-2) on Saturday afternoon. Ohio State won its first five games of the season, but it fell to then-No. 3 Oregon in one of the most thrilling games of the season two weeks ago. Nebraska has lost two of its last four games, getting blown out by then-No. 16 Indiana in a 56-7 final last week. The Buckeyes have won seven straight games against Nebraska, including a 26-17 win over the Cornhuskers in the most recent meeting (2021). Ohio State safety Lathan Ransom and Nebraska running back Rahmir Johnson are among the notable players listed as out on the availability report. 

Kickoff is set for noon ET at Ohio Stadium in Columbus. The Buckeyes are 25.5-point favorites, per SportsLine consensus, in the latest Ohio State vs. Nebraska odds. The over/under for total points is 48.5, up two points from the opener. Before entering any Nebraska vs. Ohio State picks, you’ll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it is a sizzling 14-7 on all top-rated picks over the past four weeks of this season. Anyone following at sportsbooks and on betting apps has seen strong returns.

The model has set its sights on Nebraska vs. Ohio State. You can head to SportsLine to see its picks. Here are several college football betting lines for the Ohio State vs. Nebraska game:

• Ohio State vs. Nebraska spread: Ohio State -25.5
• Ohio State vs. Nebraska over/under: 48.5 points
• Ohio State vs. Nebraska money line: Ohio State -4762, Nebraska +1500
• Ohio State vs. Nebraska picks: See picks here
• Ohio State vs. Nebraska streaming: FuboTV (Try for free)

Why Ohio State can cover

Ohio State still controls its own destiny for a spot in the new 12-team College Football Playoff, despite its narrow loss to Oregon two weeks ago. The Buckeyes had a bye week to reset following that loss, and they have won five games by at least 28 points this season. Senior quarterback Will Howard commands the explosive offense with 1,574 yards and 14 touchdowns after finishing with a season-high 326 yards against Oregon.

He has two of the top wide receivers in the country at his disposal in Jeremiah Smith and Emeka Egbuka, who have combined for more than 1,000 yards and 13 touchdowns. Running backs Quinshon Judkins (491 rushing yards) and TreVeyon Henderson (424 yards) provide balance to Ohio State’s lethal attack. The Buckeyes have dominated this head-to-head series, winning seven straight meetings while covering the spread in six of the last eight games. See which team to pick here. 

Why Nebraska can cover

Nebraska is coming off easily its worst showing of the season, making this a buy-low spot. The Cornhuskers won five of their first six games this year, including blowout wins over Colorado and Purdue. Their only other loss came in overtime against then-No. 24 Illinois, so they have been a competitive team. 

Freshman quarterback Dylan Raiola has completed 66% of his passes for 1,579 yards and nine touchdowns, while sophomore running back Dante Dowdell has 350 yards and five scores. Ohio State is in a letdown spot following its loss to Oregon, especially since it has a road game at No. 3 Penn State coming up next week. The Cornhuskers covered the spread as 14-point home underdogs when these teams met last season. See which team to pick here. 

How to make Ohio State vs. Nebraska picks

The model has simulated Nebraska vs. Ohio State 10,000 times and the results are in. The model is leaning Over, and it’s also generated a point-spread pick that is hitting in 60% of simulations. You can only see the pick at SportsLine.

So who wins Ohio State vs. Nebraska, and which side of the spread is hitting 60% of the time? Visit SportsLine now to see which side of the Nebraska vs. Ohio State spread to jump on, all from the advanced computer model that’s up well over $2,000 on its top-rated college football spread picks since its inception, and find out.