They’ll all be looking to dethrone the two-time defending Super Bowl champion Kansas City Chiefs, who once again look like they’ll be among the NFL’s elite. However, there are still far too many unknowns before we can even think about what the playoff picture might look like. (Then again, that won’t stop us from trying to predict how the 2024 season will unfold anyway.)

One of the greatest variables this season will be injuries, and not all of the NFL’s 32 teams will go into their season-openers 100% healthy.

Here’s a look at some of the most notable Week 1 injury concerns:

McCaffrey tweaked his calf during camp in early August and didn’t play in any of the Niners’ preseason games. However, he’s been practicing on a regular basis and should be good to go on Monday night vs. the Jets.

Herbert was diagnosed with a plantar fascia injury in his foot in late July and was in a walking boot for two weeks. He has gradually been ramping up his activity and should be fine to start Sunday, despite his questionable designation.