NFL parlay picks are popular throughout every season, but that will especially be the case with the 2025 NFL playoffs. You can create plenty of Wild Card Weekend NFL parlays, with bets including spread picks, over/under predictions, and NFL player props. The NFL Wild Card Weekend schedule starts on Saturday with Chargers vs. Texans (+2.5, 41.5) and Ravens vs. Steelers (+9.5, 43.5). Despite the high Wild Card NFL odds in that game, the Ravens will be without star receiver Zay Flowers, who has been ruled out with a knee injury.

Eagles vs. Packers (+4.5, 45.5) on Sunday has a pair of intriguing players to utilize as first touchdown scorers in your Wild Card Weekend NFL bets, Saquon Barkley (+400 on FanDuel) and Josh Jacobs (+500). Both teams’ quarterbacks are banged-up, which could lead to the teams leaning more on the run game. Inserting one of these into a Wild Card Weekend NFL parlay and stringing together other NFL best bets could lead to a strong payout. Before making any Wild Card Weekend NFL picks and NFL parlays, you need to see the epic Wild Card Weekend NFL parlay from SportsLine’s proven computer simulation model that pays out over $1.7 million for a $10 bet. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the 2025 NFL playoffs on a 31-14 betting hot streak on top-rated NFL picks this year, a stunning 69% success rate. Longer term, it is on a 211-142 roll on top-rated NFL picks that dates back to the 2017 season and a 65-35 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone following at sportsbooks and on betting apps could have seen strong returns.

Now that the simulation model has had a chance to digest the Wild Card Weekend NFL odds, it’s locked in its betting picks, taking into account its NFL projections from 10,000 simulations, to form a 6-leg NFL parlay that pays out over $1.7 million for a $10 bettor. You can only see the picks and full parlay by heading to SportsLine.

Top Wild Card Weekend NFL parlay picks

For Wild Card Weekend, one of the picks featured in the 6-leg parlay is Kyren Williams scoring two touchdowns in the Rams vs. Vikings matchup on Monday at +305 odds. No NFL player has more touchdowns than Williams (31) since the start of last season, despite missing six games, and that includes eight multi-touchdown games over that span. He’s also averaging 1.38 touchdowns in home games this season, the most among all running backs.

The Vikings are also susceptible to running backs finding the endzone versus them early and often. Detroit’s Jahmyr Gibbs scored four touchdowns versus Minnesota last week, while six of the last seven touchdowns that the Vikings have allowed have come via opposing running backs. The team’s run defense has also become a weak point as of late, as the Vikings have allowed 127.7 rushing yards over their last six games, compared to 74.7 over their first 11 games. See the rest of the picks in the Wild Card Weekend NFL parlay here.

How to make NFL parlay picks for a payout of over $1.7 million

The parlay also includes five additional picks from SportsLine’s computer simulation model, including three first NFL touchdown-scorer props that pay out at least 10-1. You can only see the picks and the full parlay at SportsLine.

What are the top NFL picks for Wild Card Weekend that can be combined into a parlay that returns over $1.7 million on just a $10 bet? And what optimal first touchdown scorer props pay out 10-1 or higher? Visit SportsLine now to see the top Wild Card Weekend NFL picks from SportsLine’s proven simulation model that can be combined for a parlay that pays over $1.7 million, and find out.