The Detroit Pistons (1-4) will try to build on their first win of the season when they host the New York Knicks (2-2) on Friday night. Detroit snapped its season-opening four-game losing streak with a 105-95 win at Philadelphia on Wednesday, springing the upset as a 4-point underdog. New York is getting set for the second game of a four-game road trip after beating Miami on Wednesday. The Knicks have won 15 straight meetings between these teams after sweeping the three-game season series last year. 

Tipoff is set for 7 p.m. ET on Friday at Little Caesars Arena. New York is favored by 6.5 points in the latest Pistons vs. Knicks odds, while the over/under is 217.5 points, per SportsLine consensus. Before entering any Knicks vs. Pistons picks, you’ll want to see the NBA predictions from the model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters Week 2 of the 2024-25 NBA season on a sizzling 98-63 roll on all top-rated NBA picks dating back to last season, returning more than $2,900. Anyone following at sportsbooks and on betting apps has seen huge returns. 

The model has set its sights on New York vs. Detroit. You can head to SportsLine to see its picks. Here are several NBA odds and betting lines for Knicks vs. Pistons:

• Pistons vs. Knicks spread: Pistons +6.5
• Pistons vs. Knicks over/under: 217.5 points
• Pistons vs. Knicks money line: Pistons: +214, Knicks: -263
• Pistons vs. Knicks picks: See picks at SportsLine
• Pistons vs. Knicks streaming: FuboTV (Try for free)

Why the Pistons can cover

Detroit failed to cover the spread in its first two losses of the season, but it has bounced back with three solid performances since then. The Pistons covered the spread in losses to the Celtics and Heat before taking down Philadelphia as 4-point underdogs on Wednesday. Power forward Tobias Harris posted a double-double with 18 points and 14 rebounds in his return to Philadelphia, while shooting guard Jaden Ivey scored a team-high 23 points. 

Shooting guard Cade Cunningham leads Detroit with 25.6 points, 7.4 assists and 5.6 rebounds per game, going over the 20-point mark in all five games. Ivey is off to a strong start as well, averaging 21.2 points, 4.4 rebounds and 3.6 assists. New York is 1-4 in its last five road games dating back to last season, and it has covered the spread twice in its last six games. See which team to pick here. 

Why the Knicks can cover

This series has been extremely lopsided in recent years, as New York has won 15 consecutive meetings dating back to 2020. The Knicks swept the season series last year, including a 124-99 victory in March. They have covered the spread at an 11-3-1 clip across those 15 games, and they have won seven straight games at Detroit.

New York is coming off its first road win of the season, beating Miami as a 1.5-point favorite on Wednesday night. Power forward Karl-Anthony Towns (questionable, wrist), who was one of the biggest offseason acquisitions in the league, poured in 44 points and grabbed 13 rebounds in a breakout performance. Small forward Josh Hart also posted a double-double with 10 points and 14 rebounds, while point guard Jalen Brunson chipped in 22 points and nine assists. See which team to pick here. 

How to make Pistons vs. Knicks picks

The model has simulated Knicks vs. Pistons 10,000 times and the results are in. We can tell you that the model is leaning Over, and it’s also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

So who wins Pistons vs. Knicks, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Knicks vs. Pistons spread you need to jump on, all from the model that is on a 98-63 roll on top-rated NBA picks, and find out.