The two best players left in the men’s field at the 2024 US Open will meet Wednesday night.

World No. 1 Jannik Sinner, in search of his second career Grand Slam title and first US Open, is a -300 favorite against 2021 champion Daniil Medvedev.

Both players were imperious in their victories in the Round of 16 and have lost just one set en route to the quarterfinals. In other words, Wednesday’s match should be a box-office hit.

Let’s dive a little deeper into the match and make a pick.

Jannik Sinner vs. Daniil Medvedev odds

Sinner vs. Medvedev prediction

Sinner entered the 2024 US Open as one of the favorites, but he also was under the microscope after news broke that he tested positive for a banned substance in March.

The 2024 Australian Open champion was cleared by a tribunal, but it was still a moment that shook the sport and put added pressure on the Italian.

And it looked like the situation could have turned even more dramatic when Sinner lost the first set to Mackenzie McDonald in Round 1.

But Sinner recalibrated from there and has won 12 sets on the spin, including eight by at least four games. 

Medvedev also dropped a set in his first-round match, but he’s hardly been challenged in this tournament beyond that. The Russian has won 10 of his 12 sets by at least three games.

Medvedev also has plenty of positive experience to draw upon in this situation. Not only does he have a US Open Trophy on his mantle, but he’s also been to the semifinals in four of his last five trips to Queens. 

There are also some stylistic details that the Russian can draw upon in this contest. Like Sinner, Medvedev is an elite defensive player who boasts all-world court coverage.

Sinner wallops the ball, but Medvedev is one of a few players on the planet who can match that power with his defense. 

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Sinner has been terrific, but Medvedev has been right there with him during this fortnight and will be able to answer some difficult questions of the World No. 1.

This should be a grind and that puts value on Medvedev, who has no issue going deep into the New York night to get the job done. 

The bet: Daniil Medvedev (+230, DraftKings)