Veteran wide receiver DeAndre Hopkins was effective in Kansas City’s win over the Tampa Bay Buccaneers on Monday night. He hauled in eight catches for 86 yards and two touchdowns, marking his first trip to the end zone as a member of the Chiefs. It was the first time this season that Hopkins has eclipsed 75 receiving yards, but where will he land in the Week 10 Fantasy football rankings? The Chiefs square off against the Denver Broncos on Sunday, a defense that’s giving up just 186.6 passing yards per game, which ranks sixth in the NFL.

Will Hopkins lead you to a victory in Week 10, or should you stream a receiver like Chargers wideout Quentin Johnston, who finished with 118 receiving yards and a touchdown last week? A reliable set of Week 10 Fantasy football rankings can help answer those questions and assist in your Week 10 Fantasy football start-sit decisions, or even help you find a gem in the free agent pool the rest of your league may have missed. Before setting your Fantasy football lineups, be sure to check out the Week 10 Fantasy football rankings from the proven computer model at SportsLine.

When it comes to ranking players, SportsLine’s model beat human experts in Fantasy football for the past several seasons, especially when there were big differences in ranking. Over the course of a season, that could literally be the difference between winning your league or going home empty-handed.

The same model has a proven track record of providing Fantasy football tips, including being ahead of the curve on players like A.J. Brown, Jonathan Taylor, Derrick Henry, Christian McCaffrey, Alvin Kamara, and Jahmyr Gibbs. Anybody who banked on players like those made a run at their league title.

Now, SportsLine has simulated the entire Week 10 NFL schedule 10,000 times and released its latest Week 10 Fantasy football rankings. Head to SportsLine now to see them.

Top Week 10 Fantasy football QB rankings

Here’s a look at SportsLine’s top Week 10 Fantasy football QB picks: 

1. Jalen Hurts, Philadelphia Eagles: After a somewhat lackluster start to the season, Hurts has been playing at a high level since his bye. He is averaging 10.2 yards per pass attempt over the last four weeks and has accounted for 12 touchdowns without committing a single turnover.

2. Josh Allen, Buffalo Bills: Allen is the QB4 on the season with 20 total touchdowns and his 105.8 passer rating is the second-best of his career. He’s had four consecutive games with multiple passing touchdowns and a fifth is within reach against a Colts pass defense that ranks 26th in the NFL. 

3. Jayden Daniels, Washington Commanders: Daniels completed 15 of 22 passes for 209 yards, two touchdowns and no interceptions in Sunday’s 27-22 win over the Giants. He added eight rushes for 35 yards. For the season, Daniels is completing 71.5% of his passes for 1,945 yards, nine touchdowns and two interceptions. He’s also added 459 rushing yards and four rushing touchdowns, making him a no-brainer to include in your Week 10 Fantasy football lineups. See more top QBs here.

Top Week 10 Fantasy football RB rankings

Here’s a look at SportsLine’s top Week 10 Fantasy football RB picks: 

1. Saquon Barkley, Philadelphia Eagles: Barkley has looked rejuvenated running behind a strong Philadelphia offensive line and he’s coming off his best game of the season with 199 scrimmage yards and two touchdowns against the Jaguars. He’s already piled up 1,071 scrimmage yards and eight touchdowns in eight games with the Eagles.

2. De’Von Achane, Miami Dolphins: After piling up 265 scrimmage yards and scoring twice in his first two games, Achane only had 189 scrimmage yards and failed to score over his next four games. However, he woke up when Tua Tagovailoa returned to the lineup to balance out the Miami offense, producing 268 scrimmage yards and scoring three times in the last two weeks.

3. Jonathan Taylor, Indianapolis Colts: Taylor has scored four rushing touchdowns over his last four games and he’s finished with at least 88 rushing yards in four of his last five outings. On Sunday, Taylor and the Colts will square off against the Buffalo Bills, a defense giving up 123.4 rushing yards per game on average. See more top RBs here.

Top Week 10 Fantasy football WR rankings

Here’s a look at SportsLine’s top Week 10 Fantasy football WR picks: 

1.  A.J. Brown, Philadelphia Eagles: Brown suffered a knee injury last week against the Jags but an MRI on Monday revealed good news and he could suit up this weekend. He’s had at least five catches for 84 yards in every game that he’s finished this year and he’s scored in three of those four contests.

2. Justin Jefferson, Minnesota Vikings: Jefferson had seven catches for 137 yards in a win over the Colts on Sunday night and he’s now had at least 81 receiving yards in seven consecutive games. That streak should continue against a Jaguars pass defense that ranks 31st in the NFL.

3. Garrett Wilson, New York Jets: Wilson hauled in nine of 10 targets for 90 yards and two touchdowns in New York’s 21-13 win over the Texans last Thursday. Wilson paced the Jets in receptions in the victory and he’s expected to be heavily involved again on Sunday when New York takes on the Arizona Cardinals, a defense that’s giving up 361.4 yards per game, which ranks 25th in the NFL. See more top WRs here.

Top Week 10 Fantasy football TE rankings

Here’s a look at SportsLine’s top Week 10 Fantasy football TE picks:

1. George Kittle, San Francisco 49ers: Kittle had six catches for 128 yards and a touchdown when we last saw him in a win over the Cowboys two weeks ago and a well-timed bye week should help him overcome a couple nagging injuries he’s been playing through. Brock Purdy loves looking his way in scoring areas and that’s a big reason why he’s been TE1 in 2024.

2. Travis Kelce, Kansas City Chiefs: The first month of the season was rough from a production standpoint and from an involvement standpoint, but it’s clear now that Kansas City has come to its senses. He’s been targeted 28 times over the last two weeks and has 24 receptions for 190 yards and a touchdown.

3. Trey McBride, Arizona Cardinals: McBride gathered in three of four targets for 35 yards and had a two-yard rushing touchdown during Sunday’s 29-9 win versus the Bears. McBride has hauled in at least five receptions in four of his last five games and is averaging 10.7 yards per reception this season.  See more top TEs here.

Top Week 10 Fantasy football defense rankings 

Here’s a look at SportsLine’s top three Week 10 Fantasy football D/ST picks:

1. Bears D/ST: Chicago struggled to stop the run in a loss to Arizona last week but this is still a top-five scoring defense set to match up with a rookie quarterback. The Patriots have only topped 300 yards of total offense once this year, a Week 2 overtime loss to the Seahawks where they had a whopping 310 yards.

2. Chargers D/ST: Los Angeles ranks eighth in total defense and first in points allowed, giving up only 18 points in its last two games and holding every opponent this season to 20 points or fewer. They’ll battle a Titans offense that ranks 31st in passing on Sunday.

3. Giants D/ST: The Panthers are coming off an upset win over the Saints but only managed 246 yards of total offense in the process. Carolina ranks 29th in the NFL in scoring and 30th in total yards, which is why the Giants are a solid streaming candidate in Week 10. See more top D/ST here. 

How to get Week 10 Fantasy football rankings

Now that you know who the top three at each position are, you’ll want to see the full Week 10 Fantasy football rankings from SportsLine. The model has identified a stunner in the top 10 at tight end, and knowing who it is can give you a huge edge in your league. Head to SportsLine now to get Week 10 Fantasy football rankings. 

So who should you target in your Week 10 Fantasy football rankings, and which surprising tight end could lead you to victory? Visit SportsLine now to get Week 10 Fantasy Football rankings for every single position, all from the model that has a history of making league-winning calls, and find out.