Knowing the advantageous Fantasy football matchups is key, and you can expect to see several members of the Atlanta Falcons high in the Week 6 Fantasy football rankings. That’s because the Falcons take on the Carolina Panthers, a defense that’s giving up 33.0 points per game, which ranks dead-last in the league. That means players like quarterback Kirk Cousins and running back Bijan Robinson will be among the top Week 6 Fantasy football picks, but can you trust a player like wide receiver Darnell Mooney, who hauled in nine receptions for 105 yards and two touchdowns last week?

A reliable set of Week 6 Fantasy football rankings can help answer those questions and assist in your Week 6 Fantasy football start-sit decisions and trade evaluations, or even help you find a gem in the free agent pool the rest of your league may have missed. Before setting your Fantasy football lineups, be sure to check out the Week 6 Fantasy football rankings from the proven computer model at SportsLine.

When it comes to ranking players, SportsLine’s model beat human experts in Fantasy football for the past several seasons, especially when there were big differences in ranking. Over the course of a season, that could literally be the difference between winning your league or going home empty-handed.

The same model has a proven track record of providing Fantasy football tips, including being ahead of the curve on players like A.J. Brown, Jonathan Taylor, Derrick Henry, Christian McCaffrey, Alvin Kamara, and Jahmyr Gibbs. Anybody who banked on players like those made a run at their league title.

Now, SportsLine has simulated the entire Week 6 NFL schedule 10,000 times and released its latest Week 6 Fantasy football rankings. Head to SportsLine now to see them. 

Top Week 6 Fantasy football QB rankings

Here’s a look at SportsLine’s top Week 6 Fantasy football QB picks: 

1. Lamar Jackson, Baltimore Ravens: Jackson ranks first among Fantasy football quarterbacks entering Week 6 and he is coming off his best performance of the year last week against the Bengals. Jackson threw for 348 yards and four touchdowns while also adding 55 rushing yards for a week-winning performance.

2. Jalen Hurts, Philadelphia Eagles: Fresh off a bye week, Hurts and the Eagles draw a Browns defense that has failed to impress in 2024. After leading the NFL in total defense in 2023, the Browns rank 13th in yards allowed and are 23rd in the NFL in scoring defense. The Commanders put up 434 yards and 34 points against Cleveland last week.

3. Jordan Love Green Bay Packers: Love averaged 8.6 yards per pass attempt in a win over the Rams and now he’ll take on a suspect Cardinals pass defense. Arizona allows 7.1 net adjusted yards per pass attempt, which ranks 28th in the NFL this season. See more top QBs here.

Top Week 6 Fantasy football RB rankings

Here’s a look at SportsLine’s top Week 6 Fantasy football RB picks: 

1. Saquon Barkley, Philadelphia Eagles: Barkley’s production waned late in his career with the Giants with injuries mounting and an offensive line that did him no favors. However, he’s looked rejuvenated in Philadelphia, rushing for 435 yards and four touchdowns while also catching 12 passes for 85 yards and a touchdown over his first four games. He should be well-rested coming off a bye week and ready to handle a sizable workload.

2. Derrick Henry, Baltimore Ravens: Another superstar running back enjoying a change of scenery, Henry leads the NFL in rushing yards (572) and rushing touchdowns (6) through five weeks. With Lamar Jackson helping hold linebackers and force edge defenders to focus on containment, Henry is averaging a career-high 6.0 yards per carry as well.

3. Jahmyr Gibbs, Detroit Lions: Gibbs is part of a backfield split with David Montgomery but he’s been given at least 14 touches in every game this season and has produced 361 scrimmage yards and four touchdowns in four games. Now he’ll match up with a Dallas defense that ranks 24th in the NFL against the run. See more top RBs here.

Top Week 6 Fantasy football WR rankings

Here’s a look at SportsLine’s top Week 6 Fantasy football WR picks: 

1. CeeDee Lamb, Dallas Cowboys: After catching 135 passes for 1,749 yards and 12 touchdowns a season ago, Lamb’s 2024 statline (25-378-2) might look a little pedestrian, but he’s been consistently involved in the Dallas offense. He’s been targeted at least seven times in every game and has had at least four catches for 61 yards in every contest as well. Now he takes on a Lions defense that ranks 27th against the pass.

2. Jayden Reed, Green Bay Packers: The 28 targets he’s received over five games might be a little concerning, but remember that he had Malik Willis as his quarterback in two of those games. Jordan Love is back and he’s healthy now and Reed has made the most of his limited opportunities, catching 21 passes for 414 yards and two scores while adding 110 yards and another touchdown on eight carries.

3. Ja’Marr Chase, Cincinnati Bengals: After catching 10 passes for 97 yards in his first two games this season, Chase has turned it on and he’s been the catalyst for a Cincinnati offense averaging 35 points per game the last three weeks. He has 19 catches for 396 yards and five touchdowns during that span and had 10-193-2 last week against the Ravens. See more top WRs here.

Top Week 6 Fantasy football TE rankings

Here’s a look at SportsLine’s top Week 6 Fantasy football TE picks:

1. Brock Bowers, Las Vegas Raiders: Bowers was extremely effective in last week’s loss against the Broncos, hauling in eight receptions on 12 targets for 97 yards and a touchdown. His 12 targets were a season-high for the rookie and he could take over as Las Vegas’ top pass-catching option in the absence of wide receiver Davante Adams.

2. Dallas Goedert, Philadelphia Eagles: Goedert brought in seven of eight targets for 62 yards in the Eagles’ 33-16 loss to the Buccaneers. Goedert has yet to score a touchdown this season, but he’s hauled in seven or more receptions in two consecutive games.

3. Jake Ferguson, Dallas Cowboys: Ferguson is one of the most consistent receiving threats for Dak Prescott. He has seen at least seven targets in every game but one, and he’s playing in what is projected to be one of the highest-scoring games on the Week 6 slate. Ferguson is averaging more than 13 PPR points per game in his last three outings despite the fact that he still hasn’t scored a touchdown. See more top TEs here.

Top Week 6 Fantasy football defense rankings 

Here’s a look at SportsLine’s top three Week 6 Fantasy football D/ST picks:

1. Texans D/ST: Houston only ranks 17th in the NFL in points allowed but ranks fourth in yards allowed. Now the Texans draw a juicy matchup against the Patriots, who are averaging only 12.4 points per game in Jerod Mayo’s first season at the helm.

2. Bills D/ST: Buffalo’s defense looked dominant in the first three weeks but struggled in losses to the Ravens and Texans. However, this could be a chance for a get-right game against a jet-lagged squad that played in London last week. The Jets rank 25th in the NFL in scoring.

3. Colts D/ST: The Colts have struggled on this side of the ball all season but the Titans are the most turnover-prone team in the NFL. Tennessee has nine giveaways in four games this season and Will Levis has already thrown two pick-sixes this year. See more top D/ST here. 

How to get Week 6 Fantasy football rankings

Now that you know who the top three at each position are, you’ll want to see the full Week 6 Fantasy football rankings from SportsLine. The model has identified a stunner in the top 10 at running back, and knowing who it is can give you a huge edge in your league. Head to SportsLine now to get Week 6 Fantasy football rankings. 

So who should you target in your Week 6 Fantasy football rankings, and which surprising RB could lead you to victory? Visit SportsLine now to get Week 6 Fantasy Football rankings for every single position, all from the model that has a history of making league-winning calls, and find out.