The No. 12 Duke Blue Devils (3-1) will play their first true road game of the season when they face the No. 17 Arizona Wildcats (2-1) on Friday night. Duke suffered its first loss of the campaign against then-No. 19 Kentucky in Atlanta last week, but it responded with an 86-35 win over Wofford on Saturday. Arizona opened the season with a pair of blowout wins before falling to Wisconsin in a 103-88 final last Friday. This is the first meeting between the Blue Devils and Wildcats in Tucson since 1991. 

Tipoff is set for 10:30 p.m. ET on Friday at McKale Memorial Center. Arizona is favored by 1 point in the latest Arizona vs. Duke odds, while the over/under is 160.5 points, per SportsLine consensus. Before entering any Duke vs. Arizona picks, you’ll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 3 of the 2024-25 season on a 156-114 betting roll (+1762) on all top-rated college basketball picks dating back to 2023. Anyone following at sportsbooks and on betting apps has seen huge returns.

The model has set its sights on Duke-Arizona. You can head to SportsLine to see its picks. Here are several college basketball betting lines for the game:

• Arizona vs. Duke spread: Arizona -1
• Arizona vs. Duke over/under: 160.5 points
• Arizona vs. Duke money line: Arizona: -124, Duke: +104
• Arizona vs. Duke picks: See picks here
• Arizona vs. Duke streaming: FuboTV (Try for free)

Why Arizona can cover

Arizona has already notched a pair of blowout wins at home this season, starting with a 93-64 win over Canisius. Veteran guard Caleb Love had 17 points, six assists and four rebounds, while junior guard Jaden Bradley added 15 points on 7 of 10 shooting. The Wildcats easily covered the spread as 33-point favorites in a 102-44 win over Old Dominion in their other home game, as Tennessee transfer Tobe Awaka had 18 points and 15 rebounds. 

Awaka had nine points and 13 rebounds in a loss at Wisconsin last Friday, as the Wildcats were unable to overcome a 41-point performance from Badgers star John Tonje. Love played three years at North Carolina before transferring to Arizona last season, scoring 28 points when the Tar Heels beat Duke in the 2022 Final Four. The Wildcats are 17-1 in their last 18 home games, and they are 19-1 in their last 20 November games. See which team to pick here. 

Why Duke can cover

Duke has posted three blowout wins of its own so far this season, scoring more than 85 points in victories over Maine, Army and Wofford. The Blue Devils were 26-point favorites in their 86-35 win over Wofford last Saturday, allowing their fewest points in a game since 1960. They led by as many as 51 points in their most lopsided win of the season, bouncing back from their loss to Kentucky in the Champions Classic. 

Five-star freshman guard Cooper Flagg leads Duke with 16.3 points, 9.5 rebounds and 4.0 assists per game, finishing with 26 points and 11 rebounds against Kentucky. Freshman guard Kon Knueppel is averaging 14.8 points and 4.0 rebounds, while junior guard Tyrese Proctor is adding 12.8 points. The Blue Devils have covered the spread in six of their last eight games. See which team to pick here. 

How to make Arizona vs. Duke picks

The model has simulated Duke vs. Arizona 10,000 times and the results are in. We can tell you that the model is leaning Under, and it’s also generated a point-spread pick that is hitting in almost 60% of simulations. You can only see the pick at SportsLine.

So who wins Arizona vs. Duke, and which side of the spread hits almost 60% of the time? Visit SportsLine now to see which side of the Duke vs. Arizona spread you need to jump on, all from the model that is on a 156-114 roll on top-rated college basketball picks, and find out.