MELBOURNE, Australia — Defending champion Jannik Sinner and 10-time Australian Open winner Novak Djokovic have landed in opposite sides of the draw for the season’s first major, ruling out a replay of last year’s semifinal match.

Sinner upset Djokovic in the semifinals here last year before coming back to beat Daniil Medvedev in the final 3-6, 3-6, 6-4, 6-4, 6-3 for his first Grand Slam singles title.

Top-ranked Sinner has a first-round match against Nicolas Jarry and also has Taylor Fritz, Ben Shelton and Medvedev in his half of the draw. Fritz will open against fellow American Jenson Brooksby.

Djokovic and No. 3 Carlos Alcaraz could meet in the quarterfinals, with a possible semifinal against No. 2 Alexander Zverev.

At Thursday’s draw to set the brackets for the singles fields, defending champions Sinner and Aryna Sabalenka walked into the official ceremony holding their trophies.

Sabalenka won her second consecutive title at Melbourne Park in 2024 by defeating Zheng Qinwen 6-3, 6-2 in the final. Sabalenka will be attempting to win a third straight women’s singles title at Melbourne Park, something last accomplished by Martina Hingis from 1997 to 1999.

Sabalenka drew a tough opening match against 2017 U.S. Open champion Sloane Stephens, and Sabalenka has 17-year-old Mirra Andreeva and Zheng in her section.

“I have a lot of great memories, and to be back here … as a two-time Australian Open champion, it’s definitely something special,” Sabalenka, who won the Brisbane International title last week, said at the draw ceremony. “I hope that I can keep doing what I’m doing here in Australia.”

Third-seeded Coco Gauff is a potential semifinal rival for Sabalenka. Gauff has a challenging first-round match against former Australian Open champion Sofia Kenin and is in the same section of the draw as seventh-seeded Jessica Pegula.

The Australian Open will start Sunday morning in Melbourne (Saturday night ET) and run for 15 days.

Djokovic will be playing in his first event alongside new coach Andy Murray, his former on-court rival and a three-time major champion. Nobody has won the men’s title at Melbourne Park more often than Djokovic, although he said he still feels trauma from the one year he wasn’t allowed to play.

Nick Kyrgios, the 2022 Wimbledon runner-up who withdrew from an exhibition against Djokovic this week because of an abdominal strain, will face Jacob Fearnley in the first round if the mercurial Australian is fit enough to contest his first major since the 2022 US Open. Kyrgios is in the same section as Zverev.