Draper, ranked No 27, will play the winner of the match between Norwegian Casper Ruud, the No 7 seed, and Canadian Felix Auger-Aliassime next.

In the previous round of the Cincy Open, Jack Draper edged out Spanish qualifier Jaume Munar (7-5, 3-6, 7-6 (5)).

Tsitsipas, ranked No 11, beat German Jan-Lennard Struff (4-6, 6-4, 6-3) in the previous round of the Cincy Open.

Cincinnati Masters 1000, other second-round results (Lindner Family Tennis Center, hard, USD 6.795.555, most recent results first):

• Casper Ruud vs. Felix Auger-Aliassime
• Gael Monfils vs. Carlos Alcaraz
• Holger Rune (15) beat Nuno Borges (Q): 6-3, 7-6 (8)
• Ben Shelton (12) beat Tomas Martin Etcheverry: 6-7 (6), 7-6 (7), 6-3
• Brandon Nakashima (WC) beat Arthur Fils: 7-5, 7-6 (3)
• Andrey Rublev (6) beat Zhizhen Zhang: 6-4, 6-3
• Fabian Marozsan beat Grigor Dimitrov (8): 4-6, 6-4, 6-3
• Pablo Carreno Busta beat Max Purcell (WC): 6-3, 6-3
• Hubert Hurkacz (5) beat Yoshihito Nishioka (Q): 3-6, 7-6 (4), 6-1
• Flavio Cobolli beat Luciano Darderi: 7-6 (4), 3-1 ret.
• Alexander Zverev (3) beat Karen Khachanov: 6-3, 6-2
• Jiri Lehecka beat Daniil Medvedev (4): 7-6 (2), 6-4
• Jordan Thompson beat Sebastian Baez: 6-2, 6-4
• Frances Tiafoe beat Lorenzo Musetti (14): 6-3, 6-2
• Jannik Sinner (1) beat Alex Michelsen (Q): 6-4, 7-5