Justin Herbert and the Los Angeles Chargers will host Bo Nix and the Denver Broncos for a pivotal AFC West showdown on Thursday Night Football. Kickoff from SoFi Stadium is at 8:15 p.m. ET. These two rivals squared off on Oct. 13, with Los Angeles recording a 23-16 victory on the road. According to the latest Broncos vs. Chargers odds, Los Angeles is a 2.5-point favorite, while the over/under for total points scored is 41.5. The Chargers are -149 money line favorites (risk $149 to win $100), while the Broncos are +125 underdogs. If you are looking for NFL picks, AI predictions or NFL DFS picks for Chargers vs. Broncos, SportsLine has you covered with its proven model, AI PickBot and team of experts. They even have one pick that returns a whopping +10000, so be sure to see what they have to say.

Advanced NFL model simulates Broncos vs. Chargers 10,000 times 

SportsLine’s model enters Week 16 of the 2024 NFL season on an incredible 27-11 betting hot streak on top-rated NFL picks this year. Longer term, it is on a 207-139 roll on top-rated NFL picks that dates back to the 2017 season and a 61-32 roll on top-rated NFL picks since Week 7 of 2022. The model has revealed its best bets for Broncos vs. Chargers and is backing the Under (42) to hit in well over 50% of simulations. You can find the model’s picks on the spread and money line here. 

Self-learning AI reveals top player props 

SportsLine AI hit a whopping 2,131 4.5- and 5-star sports betting picks since the start of last season. Now it has locked in its top player props for players like Justin Herbert, Bo Nix, Courtland Sutton and Ladd McConkey. One of its top picks is Herbert staying Under 20.5 passing completions, which has earned a 4-star rating. The AI PickBot is calling for Herbert to finish with 17.1 completions on TNF. You can see all the top-rated NFL prop picks from the AI PickBot here.

NFL Vegas expert picks revealed for TNF 

SportsLine has an expansive team of NFL experts who provide quality betting advice for every game on the schedule. NFL expert Matt Severance, who is on a blistering 23-7 roll on Broncos games, has analyzed this AFC West rivalry from every angle and locked in his best bet for TNF right here.

Eric Cohen, who is 123-53 since Week 4, has revealed his exact score prediction for Broncos vs. Chargers, which returns a whopping +10000. That pick, along with his prediction for the other 15 games, is available here. SportsLine’s advanced computer model has also locked in its exact score predictions for Chargers vs. Broncos, and every Week 16 NFL game right here.

NFL DFS picks from top experts 

SportsLine has a DFS optimizer that simulates every game 10,000 times and uses info from the SportsLine Projection Model and DFS Professional Millionaire Mike McClure to identify top DFS picks/plays for any slate on sites like FanDuel and DraftKings. Their NFL DFS Optimizer has Chargers wide receiver Ladd McConkey as its top overall player to include in your TNF DFS picks. Here are its complete Broncos vs. Chargers NFL DFS rankings. 

DFS Professional Millionaire Mike McClure has locked in his top NFL DFS picks for Chargers vs. Broncos on Thursday Night Football. He’s building his NFL DFS lineups around Chargers quarterback Justin Herbert. McClure is also targeting another undervalued player who could explode for huge numbers on TNF. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of McClure’s NFL DFS picks, right here.

Where to bet on Thursday Night Football

Here are several sportsbooks to bet on NFL games this week, along with the various NFL sportsbook promos they currently offer.