Samuel has missed the last two games and Hamlin the last three, while Rapp returned from a two-game absence last week against the Jets. Samuel is listed questionable while the other three do not have a designation which generally means they will be available.

The offensive line is a tricky spot because you can’t sit out all five players, but McDermott did say, “Our starting O-line will be dressed, but they will not be out there, ideally. A lot of those guys who have been busting their butts as backups all year long, we’re going to give them an opportunity to see what they can do.”

That would mean players like rookies Sedrick Van Pran-Granger and Tylan Grable, plus young veterans such as Richard Gouraige, Alec Anderson and Ryan Van Demark.

Also, the Bills announced that practice squad quarterback Mike White was signed to the 53-man roster, and linebacker Nicholas Morrow was released to make room. That means White can be the backup to starter Mitch Trubisky Sunday.