Alabama prevailed against Georgia in a thriller last week, causing the Bulldogs to drop from No. 2 to No. 5 in the AP poll heading into the Week 6 college football schedule. They opened as 20-point favorites in their matchup against Auburn, but they have jumped to -23.5 in the latest Week 6 college football odds. Auburn has lost three of its last four games and is going on the road for the first time this season following a 27-21 loss to Oklahoma last week. Should you fade the Tigers with your Week 6 college football bets?

Meanwhile, Alabama will try to back up its new No. 1 ranking when it travels to Vanderbilt as a 22.5-point favorite in the Week 6 college football spreads. This has been a lopsided series, as the Crimson Tide have won 23 consecutive meetings, with the last three being decided by 34-plus points. Before locking in any Week 6 college football picks on those games or others, be sure to see the college football betting guide from legendary Vegas handicapper Bruce Marshall. 

For years Vegas-based Marshall was synonymous with The Gold Sheet, the famed sports betting newsletter. With a background in play-by-play work and sports information while in college, Marshall joined TGS in 1981 when hired by the legendary Mort Olshan and served as executive editor for many years. 

An in-demand guest on numerous sports talk radio and TV shows across the country, Bruce’s vast array of editorial work has been featured in the Las Vegas Review-Journal, the New York Post and many other outlets. He has won various handicapping titles and also is working on several book projects. Bruce also enters the Week 6 college football schedule on a 17-7 roll (+923) on his official SportsLine college football spread picks. 

Now, using his Tech Corner technique that evaluates all the trends and the latest college football odds, Marshall has turned his attention to college football betting for Week 6 and revealed picks for each matchup. Head here to see every pick.

Top college football predictions for Week 6

One of the top college football picks Marshall is recommending for Week 6: He’s backing the No. 23 Indiana Hoosiers to cover the 13.5-point spread against Northwestern in a 3:30 p.m. ET matchup. Indiana has a 5-0 record for the first time since 1967, which was the last time the program shared a Big Ten title. The Hoosiers have won all five of those games by at least 14 points, including their 42-28 win over Maryland last week.

Senior quarterback Kurtis Rourke has 1,372 passing yards and 11 touchdowns, while senior running backs Justice Ellison and Ty Son Lawton have combined for more than 600 rushing yards and 11 scores. They are facing a Northwestern defense that allowed 24 points in a loss at Washington its last time out. The Hoosiers have gone Over the total in five straight road games, so Marshall also likes the Over (41.5) in this contest. See which other picks to make here. 

How to make college football picks for Week 6

Marshall has evaluated every other matchup and he’s found an alarming 23-5 betting trend you need to know this week. Get betting analysis for each matchup at SportsLine.

So what college football picks can you make with confidence, and what alarming trend do you need to know about? Check out the latest college football odds below, then visit SportsLine to see which teams to back, all from the legendary Vegas expert who has won multiple handicapping titles, and find out.

Week 6 college football odds 

See full Week 6 college football picks, odds and predictions here.

Friday, Oct. 4

Jacksonville State at Kennesaw State (+16.5, 48.5)

Houston at TCU (-17, 51.5)

Syracuse at UNLV (-6.5, 57)

Michigan State at Oregon (-23.5, 52.5)

Saturday, Oct. 5

Missouri at Texas A&M (-2.5, 48.5)

UCLA at Penn State (-28, 46.5)

Auburn at Georgia (-22.5, 51.5)

Ole Miss at South Carolina (+8, 53.5)

Iowa at Ohio State (-18.5, 45.5)

Alabama at Vanderbilt (+22.5, 54.5)

Clemson at Florida State (+14.5, 46.5)

Tennessee at Arkansas (+13.5, 57.5)

Baylor at Iowa State (-12.5, 45)

USC at Minnesota (+8.5, 49.5)

Michigan at Washington (-1.5, 41.5)

Miami at California (+10.5, 54)

Texas Tech at Arizona (-6.5, 64)